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Date Published: 13/01/2022
Abstract Views: 226
Views PDF: 170
DOI: https://doi.org/10.51298/vmj.v509i2.1846
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Mỹ Hạnh, B. ., & Thị Minh Lý, N. . (2022). LOW MOLECULAR WEIGHT HEPARIN COMPARED TO ANTICOAGULANT RIVAROXABAN FOR THE PREVENTION OF VENOUS THROMBOEMBOLISM IN POSTOPERATIVE PATIENT. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1846

LOW MOLECULAR WEIGHT HEPARIN COMPARED TO ANTICOAGULANT RIVAROXABAN FOR THE PREVENTION OF VENOUS THROMBOEMBOLISM IN POSTOPERATIVE PATIENT

Bùi Mỹ Hạnh1,2,, Nguyễn Thị Minh Lý1,2
1 Hanoi Medical University
2 Hanoi Medical University Hospital

Main Article Content

Abstract

Objectives: To compare the results of postoperative venous thromboembolism prophylaxis with low molecular weight heparin (LMWH) and rivaroxaban. Subjects and methods: The study was design retrospectively, 30,010 surgical patients with >18 years of age were recruited from January 1, 2017 to September 31, 2018 to received anticoagulation with LMWH or rivaroxaban. Of these, 25.479 patients were prevented by LMWH and 4.531 patients were prevented by rivaroxaban. Result: The number of postoperative VTE patient accounting for 0,6% in LMWH group (146/25479), which was higher than the figure of rivaroxaban group of 0,3% (15/4531) and the proportion of patients developing VTE in 90 days after hospital discharge of the LMWH group was 0,5% (138/25479), compared to rivaroxaban group with percentage of 0,3% (14/4531).The rate of developing bleeding complications were higher in LMWH prophylactic group with 6,2% (1585/25479) in comparison with rivaroxaban group with 4,5% (206/4531). The difference was statistically significant with p < 0.05. Conclusion: Rivaroxaban reduced the rate of VTE recurrence and did not increase the risk of bleeding complication in postoperative patients compared with LMWH, the difference was statistically significant.

Article Details

Keywords

Rivaroxaban, Low molecular weight heparin, surgery

References

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