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Issue: Vol. 561 No. 3 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v561i3.18503
Date Published: 11/08/2026
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How to Cite
Nguyễn, D. H. (2026). MULTIPARAMETRIC MRI VALUE OF DIFFUSION TENSOR IMAGING, MAGNETIC RESONANCE SPECTROSCOPY, AND PERFUSION IMAGING IN DIFFERENTIATING HIGH-GRADE GLIOMAS FROM SOLITARY BRAIN METASTASIS. Vietnam Medical Journal, 561(3). https://doi.org/10.51298/vmj.v561i3.18503

MULTIPARAMETRIC MRI VALUE OF DIFFUSION TENSOR IMAGING, MAGNETIC RESONANCE SPECTROSCOPY, AND PERFUSION IMAGING IN DIFFERENTIATING HIGH-GRADE GLIOMAS FROM SOLITARY BRAIN METASTASIS

Duy Hùng Nguyễn1,2,
1 Trường Đại học Y Hà Nội
2 Bệnh viện Việt Đức

Main Article Content

Abstract

Objective: To evaluate the efficacy of Diffusion Tensor Imaging (DTI), Magnetic Resonance Spectroscopy (MRS), and Magnetic Resonance Perfusion (MRP) in differentiating High-Grade Gliomas (HGG) from Solitary Brain Metastases (SBM).


Methods: This retrospective study included 41 patients (24 HGG, 17 SBM) who underwent multiparametric MRI prior to intervention. FA, MD, rCBV, rCBF, and metabolic ratios (Cho/NAA, Cho/Cr) were measured in the intratumoral (t) and peritumoral (p) regions. All findings were correlated with histopathology. Diagnostic performance was assessed using ROC curve analysis and multivariate logistic regression.


Results: In the intratumoral region, only MDt (P = 0.011) and Cho/NAAt (P < 0.001) showed significant differences. Conversely, most peritumoral parameters (except FAp) exhibited distinct differences between the two groups. The peritumoral Cho/Crp ratio achieved the highest diagnostic performance (AUC 0.939) and was the sole independent predictor in the multivariate model. At a cutoff of 1.22, Cho/Crp yielded a sensitivity (Se) of 87.5%, specificity (Sp) of 94.2%, and accuracy (AC) of 90.3%.


Conclusion: Multiparametric MRI in the peritumoral region is highly valuable for differentiating HGG from SBM. Cho/Crp is the strongest independent predictor, while rCBVp provides optimal specificity for HGG diagnosis.

Keywords

Diffusion Tensor Imaging, Magnetic Resonance Spectroscopy, and Perfusion Imaging, High-Grade Gliomas, Solitary Brain Metastasis

Article Details

References

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