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Issue: Vol. 561 No. 3 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v561i3.18577
Date Published: 11/08/2026
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Downloads 31
How to Cite
Trần, L. M. N., Lê, V. Q., & Đỗ, X. T. (2026). ASSOCIATION BETWEEN PLASMA MICRORNA-132 EXPRESSION LEVELS AND DISEASE STAGE IN PATIENTS WITH DEPRESSION. Vietnam Medical Journal, 561(3). https://doi.org/10.51298/vmj.v561i3.18577

ASSOCIATION BETWEEN PLASMA MICRORNA-132 EXPRESSION LEVELS AND DISEASE STAGE IN PATIENTS WITH DEPRESSION

Lê Minh Nguyệt Trần1,2, , Văn Quân Lê3, Xuân Tĩnh Đỗ1,2
1 Bộ môn Tâm Thần, Học viện Quân y
2 Khoa Tâm thần, Bệnh viện Quân y 103
3 Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

Objective: To evaluate the association between plasma microRNA-132 (miR-132) expression levels and disease stage in patients with depression.


Methods: A prospective, descriptive, cross-sectional study was conducted on 60 adult patients (aged 18-60 years) with depression. The expression levels of miR-132 were quantified using digital polymerase chain reaction (dPCR).


Results: Patients who had used psychotropic medications prior to hospital admission showed significantly lower miR-132 expression levels compared to those who had not (p = 0.047). The expression levels of miR-132 in the moderate and severe groups according to ICD-10 were significantly higher than in the mild depression group (0.335 copies/µL vs. 0.239 copies/µL, p = 0.048; and 0.431 copies/µL vs. 0.239 copies/µL, p = 0.025). No significant difference was observed between the moderate and severe depression groups (p > 0.05).


Conclusion: Plasma microRNA-132 expression levels may serve as a potential indicator of disease stage in patients with depression.

Keywords

Depression, microRNA-132, Digital Polymerase Chain Reaction (dPCR)

Article Details

References

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