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Date Published: 13/01/2022
Abstract Views: 164
Views PDF: 131
DOI: https://doi.org/10.51298/vmj.v509i2.1860
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Bảo Ngọc, L. ., Gia Hoàng Linh, L. ., & Đức Minh, Đỗ . (2022). THE ASSOCIATION BETWEEN ABCG2 Q141K VARIANT AND SERUM URIC ACID CONCENTRATION IN ADULTS. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1860

THE ASSOCIATION BETWEEN ABCG2 Q141K VARIANT AND SERUM URIC ACID CONCENTRATION IN ADULTS

Lý Bảo Ngọc1, Lê Gia Hoàng Linh2, Đỗ Đức Minh2,
1 Pham Ngoc Thach University of Medicine
2 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Background: Serum uric acid concentration is influenced by genetic factor. The present study aimed to investigate the association between ABCG2 Q141K variant and serum uric acid concentration in Vietnamese adults. Objectives and methods: In this case series study, 150 participants were enrolled and genotyped for ABCG2 Q141K variant using Sanger sequencing. Results: Frequency of ABCG2 Q141K variant was 54% in Vietnamese adults. Q141K was not significantly associated with serum uric acid concentration in Vietnamses adults by statistical models. Q141K inclined to elevate serum uric acid level. Conclusion: The association between ABCG2 Q141K variant and serum uric acid concentration is not established in Vietnamese adults.

Article Details

Keywords

serum uric acid concentration, single nucleotide polymorphism, Q141K, ABCG2 gene

References

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