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Issue: Vol. 561 No. 3 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v561i3.18610
Date Published: 11/08/2026
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Downloads 28
How to Cite
Trịnh, T. X. V., Nguyễn, V. H. P., Đỗ, T. K. Y., Nguyễn, T. T. O., & Trần, N. T. (2026). PREDICTIVE VALUE OF CHANGES IN UTERINE ARTERY PULSATILITY INDEX BETWEEN THE FIRST AND THIRD TRIMESTERS FOR PLACENTA-RELATED ADVERSE OUTCOMES IN SINGLETON PREGNANCIES. Vietnam Medical Journal, 561(3). https://doi.org/10.51298/vmj.v561i3.18610

PREDICTIVE VALUE OF CHANGES IN UTERINE ARTERY PULSATILITY INDEX BETWEEN THE FIRST AND THIRD TRIMESTERS FOR PLACENTA-RELATED ADVERSE OUTCOMES IN SINGLETON PREGNANCIES

Trần Xuân Vinh Trịnh1,2, Vũ Hà Phúc Nguyễn1,2, Thị Kim Yến Đỗ2, Thị Thuý Oanh Nguyễn1, Nhật Thăng Trần1,2,
1 Đại học Y Dược thành phố Hồ Chí Minh
2 Bệnh viện Nguyễn Trãi

Main Article Content

Abstract

Objective: To evaluate the association between changes in mean uterine artery pulsatility index (mUtA-PI) from the first to the third trimester and adverse placenta-related pregnancy outcomes in singleton pregnancies.


Methods: A retrospective cohort study was conducted on 353 singleton pregnancies undergoing uterine artery Doppler assessment in both the first and third trimesters at University of Medicine and Pharmacy at Ho Chi Minh City Hospital (September 2023–March 2024). The mUtA-PI was standardized using multiples of the median (MoM) and the 95th percentile according to gestational age.


Results: Among 353 pregnancies, there were 9 cases of placenta-related disease (PRD) (2.5%) and 23 cases of constitutionally small (CS) infants (6.5%). Third-trimester mUtA-PI (MoM) showed the highest predictive performance for PRD (AUC = 0.76; p = 0.007), whereas first-trimester mUtA-PI and ΔmUtA-PI were not statistically significant. Most abnormal third-trimester UtA-PI cases were newly developed on a previously normal first-trimester background (85.7%). The group transitioning from normal to abnormal had the highest PRD rate (25%).


Conclusion: Third-trimester mUtA-PI has moderate predictive value for PRD, while its change does not improve predictive performance, and repeat uterine artery Doppler assessment may enhance risk stratification for placenta-related disorders.

Keywords

uterine artery Doppler, pulsatility index, placenta-related disease

Article Details

References

1. Gómez, O., et al., Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation. Ultrasound Obstet Gynecol, 2008. 32(2): p. 128-32.
2. Bhide, A., et al., ISUOG Practice Guidelines (updated): use of Doppler velocimetry in obstetrics. Ultrasound in Obstetrics & Gynecology, 2021. 58(2): p. 331-339.
3. Trịnh, T.X.V., et al., Khoảng tham chiếu của chỉ số xung động mạch tử cung ở ba tháng cuối thai kỳ tại Bệnh viện Đại học Y Dược thành phố Hồ Chí Minh. Tạp chí Phụ sản, 2025. 22(5): p. 50-55.
4. Villar, J., et al., International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet, 2014. 384(9946): p. 857-68.
5. ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol, 2019. 133(1): p. 1.
6. Zhi, R., et al., Association between transabdominal uterine artery Doppler and small-for-gestational-age: a systematic review and meta-analysis. BMC Pregnancy Childbirth, 2023. 23(1): p. 659.
7. Llurba, E., et al., Emergence of late-onset placental dysfunction: relationship to the change in uterine artery blood flow resistance between the first and third trimesters. Am J Perinatol, 2013. 30(6): p. 505-12.
8. Bonacina, E., et al., Role of routine uterine artery Doppler at 18-22 and 24-28 weeks’ gestation following routine first-trimester screening for pre-eclampsia. Ultrasound Obstet Gynecol, 2025. 65(1): p. 63-70.