Article Sidebar

PDF
Issue: Vol. 562 No. 3 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v562i3.18681
Date Published: 13/08/2026
Views 0
Downloads 0
How to Cite
Trần, Q. T., & Cao, V. H. (2026). PEDIATRIC ARTERIAL ISCHEMIC STROKE FOLLOWING MINOR HEAD TRAUMA: A THREE-CASE SERIES WITH HETEROGENEOUS IMAGING FEATURES AND PATHOPHYSIOLOGICAL MECHANISMS. Vietnam Medical Journal, 562(3). https://doi.org/10.51298/vmj.v562i3.18681

PEDIATRIC ARTERIAL ISCHEMIC STROKE FOLLOWING MINOR HEAD TRAUMA: A THREE-CASE SERIES WITH HETEROGENEOUS IMAGING FEATURES AND PATHOPHYSIOLOGICAL MECHANISMS

Quang Thanh Trần1, , Vũ Hùng Cao1
1 Bệnh viện Nhi Trung ương

Main Article Content

Abstract

Objectives: To describe the clinical manifestations, neuroimaging findings, etiological factors and outcomes of three young children with arterial ischemic stroke occurring after minor head trauma.


Subjects and methods: This descriptive case series included three children younger than 24 months diagnosed at the Neurology Center, Vietnam National Children’s Hospital. Clinical, imaging, etiological, treatment and outcome data were collected from medical records and follow-up visits.


Results: The patients were aged 10–23 months and all developed focal neurological deficits after minor trauma. Case 1 was a 23-month-old girl with acute right basal ganglia infarction in the lenticulostriate territory and early motor recovery after aspirin. Case 2 was a 10-month-old boy with focal seizures and right hemiparesis one day after a 70–80 cm fall; late MRI showed an old cystic lesion in the left putamen and right spastic hemiparesis persisted at five months. Case 3 was an 11-month-old boy with multifocal right anterior-circulation infarctions, narrowing of the right internal carotid and middle cerebral arteries, severe iron deficiency anemia and reactive thrombocytosis.


Conclusions: Stroke after minor head trauma in young children is clinically and mechanistically heterogeneous. Temporal association with trauma should not be interpreted as proof of direct causality. Early brain MRI, cerebrovascular imaging and systematic etiological evaluation are required

Keywords

pediatric arterial ischemic stroke, minor head trauma, basal ganglia infarction, lenticulostriate artery, cerebral arteriopathy

Article Details

References

1. Ferriero DM, Fullerton HJ, Bernard TJ, et al. Management of stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke. 2019;50(3):e51-e96. doi:10.1161/STR.0000000000000183
2. Landi A, Marotta N, Mancarella C, et al. Basal ganglia stroke due to mild head trauma in pediatric age: clinical and therapeutic management—a case report and 10 year literature review. Ital J Pediatr. 2011;37:2. doi:10.1186/1824-7288-37-2
3. Lingappa L, Varma RD, Siddaiahgari S, Konanki R. Mineralizing angiopathy with infantile basal ganglia stroke after minor trauma. Dev Med Child Neurol. 2014;56(1):78-84. doi:10.1111/dmcn.12217
4. Gowda VK, Manjeri V, Srinivasan VM, Sajjan SV, Benakappa A. Mineralizing angiopathy with basal ganglia stroke after minor trauma: case series including two familial cases. J Pediatr Neurosci. 2018;13(4):448-454. doi:10.4103/jpn.JPN_89_17
5. Wang G, Luan Y, Feng L, Yu J. Current status of infarction in the basal ganglia-internal capsule due to mild head injury in children using PRISMA guidelines. Exp Ther Med. 2020;19(2):1149-1154. doi:10.3892/etm.2019.8320
6. Goraya JS. Mineralizing lenticulostriate vasculopathy: an emerging risk factor for basal ganglia stroke after minor head trauma in young children. Pediatr Neurol. 2023;145:22-27. doi:10.1016/j.pediatrneurol.2023.05.008
7. Wintermark M, Hills NK, deVeber GA, et al. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the VIPS study. Stroke. 2014;45(12):3597-3605. doi:10.1161/STROKEAHA.114.007404
8. Maguire JL, deVeber G, Parkin PC. Association between iron-deficiency anemia and stroke in young children. Pediatrics. 2007;120(5):1053-1057. doi:10.1542/peds.2007-0502