TỔN THƯƠNG DA TRÊN BỆNH NHÂN XƠ CỨNG BÌ HỆ THỐNG TIẾN TRIỂN VÀ MỘT SỐ YẾU TỐ LIÊN QUAN

Abstract

Objectives: Our objective was to study the characterize dermal lesions and risk factors in patients with systemic sclerosis. Methods and Methodology: It was a cross-sectional descriptive study has conducted from July 2020 to July 2021 on 60 inpatients treated at Allergy and Clinical Immunology Center in Bach Mai Hospital. The patients met the diagnostic criteria according to the 2013 ACR/EULAR was selected. Findings: The results have shown that clinical lesions were diverse, especially skin lesions. The skin thickness – mRSS was 14.5 ± 7.9, Raynaud's phenomenon (73.3%), skin pigmentation disorder (53.3%), hair loss (46.7%), digital ulcers (31.7%), digital gangrene (28.3%), pitting scars (11.7%), skin ulcers (33.3%), telangiectasia (13.3), calcinosis (18,3%). The majority of visceral damage was interstitial lung disease accounting for 81.7%, gastrointestinal lesions 37/60 (61.7%), and pulmonary arterial hypertension 36/60 (60 %). In contrast, the minority was kidney injury, particularly glomerulonephritis, and renal crises were 13.3% and 5%, respectively. All patients tested for antinuclear antibody were positive, positive for anti-Scl-70 antibody accounted for 67.9%, the positive anticentromere antibody was 31.3%.