ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ TRUYỀN MÁU TRÊN BỆNH NHÂN THALASSEMIA TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Objective: describle the clinical, laboratory and treatment outcome of blood transfusion in thalassemia patients at Thai Nguyen central hospital. Subjects and methods: Cross-sectional description of 53 patients were diagnosed with thalassemia at Thai Nguyen Central Hospital from June 2020 to September 2021. Result: 100% of patients have iron overload in which severe iron overload accounts for 67.9%. Patients with splenomegaly and splenectomy accounted for 83%, in which the rate of patients with grade I - II splenomegaly was the highest (50.9%). The number of patients with hepatomegaly accounted for 74.4%, dark skin accounted for 58.5%, 86,8% of patients with jaundice. The average Hb concentration at admission of the patients was: 65.91 ± 12.33g/l. 20.8% of patients had positive Coombs test results. The average interval between two consecutive blood transfusions of the study group patients was 4.82 ± 1.26 weeks. The average volume of red blood cell infusion in 1 course of treatment was 477.36 ± 179.36ml. The average Hb concentration at discharge was 102±10.45g/l. The average increase in Hb concentration was 36.83 ± 13.84 g/l. The average need for blood transfusion/year is 251.58 ± 113.05 ml/kg/year. The average weekly rate of decrease in Hb concentration was 5.25±3.54g/l/week. Conclusion: All patients have some clinical features such as: hepatomegaly, dark skin, jaundice, splenomegaly. The mean Hb concentration at admission was very low (65.91 ± 12.33g/l). 20.8% of patients had a positive. Coombs test result. The need for blood transfusion of patients by year is very high (251.58 ± 113.05ml/kg/year). The rate of patients with severe iron overload is 67.9%, this subject needs to be actively chelated and monitored for complications.