THE PREDICTIVE VALUE OF THE RED BLOOD CELL DISTRIBUTION WIDTH-TO-ALBUMIN RATIO (RAR) AND THE SYSTEMIC INFLAMMATION RESPONSE INDEX (SIRI) FOR CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
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Abstract
Background: The red blood cell distribution width-to-albumin ratio (RAR) and the systemic inflammation response index (SIRI) are biomarkers reflecting inflammatory and nutritional status. However, their roles in assessing renal impairment in patients with diabetes mellitus have not been fully investigated.
Objective: To investigate the association of RAR and SIRI with renal function and to evaluate their predictive value for chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
Subjects and methods: A cross-sectional study was conducted in 255 patients with T2DM. Correlation analysis was performed to assess the relationships between inflammatory indices and renal function markers, including estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR). Multivariable logistic regression was used to identify independent predictors of CKD, and receiver operating characteristic (ROC) curve analysis was applied to evaluate the predictive performance of the model.
Results: Patients with CKD had significantly higher RAR and SIRI levels than those without CKD (p < 0.05). RAR correlated negatively with eGFR (r = −0.34; p < 0.0001) and positively with UACR (r = 0.31; p < 0.0001). SIRI also correlated negatively with eGFR (r = −0.18; p = 0.0037) and positively with UACR (r = 0.25; p < 0.0001). Independent predictors of CKD included RAR, SIRI, hemoglobin, HDL-C, and uric acid, with the model achieving an AUC of 0.8347.
Conclusion: RAR and SIRI are significantly associated with renal dysfunction in patients with T2DM and may serve as useful biomarkers for screening the risk of CKD.
Keywords
RDW-to-albumin ratio (RAR), SIRI, chronic kidney disease, type 2 diabetes mellitus
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References
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