CLINICAL, PARACLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF PEDIATRIC PATIENTS WITH ACUTE KIDNEY INJURY ADMITTED TO THE INTENSIVE CARE UNIT AT CHILDREN'S HOSPITAL 1
Main Article Content
Abstract
Background: Globally, the multicenter AWARE study reported the incidence of acute kidney injury in pediatric intensive care units reaching 26.9%. In Vietnam, updated data on this disease pattern are limited. Currently at Children’s Hospital 1, the unified application of KDIGO diagnostic criteria, along with significant advancements in intensive care techniques such as continuous renal replacement therapy, may have altered treatment outcomes over time.
Objectives: To determine the clinical, paraclinical characteristics, and treatment outcomes of pediatric patients with acute kidney injury admitted to the Intensive Care Unit at Children's Hospital 1.
Methods: A cross-sectional descriptive study was conducted from January 1, 2023, to July 31, 2025, at Children’s Hospital 1.
Results: There were 132 cases of acute kidney injury in children during the study period. The median age was 49 months (range: 10 – 120 months). Main clinical symptoms included respiratory failure (73.5%), altered mental status (66.7%), shock (39.4%), and edema (8.3%). Main paraclinical abnormalities were hyperlactatemia (40.2%), hyperkalemia (31.1%), metabolic acidosis (29.5%), and hyponatremia (25%). Stage 3 acute kidney injury accounted for 39.4%. The most common related causes were sepsis (33.3%) and pneumonia (31.1%); occurring in the context of multiple organ dysfunction syndrome which accounted for a high rate (74.2%). Main treatments included antibiotics (92.4%), mechanical ventilation (81.8%), vasopressors (77.3%), and continuous renal replacement therapy (34.8%). Primary treatment outcomes included a mortality rate of 25%and a renal function recovery rate of 63.6%.
Conclusion: Strategies for rational antibiotic management, therapeutic drug monitoring, and consideration of early indication for continuous renal replacement therapy in high-risk groups are needed to improve mortality.
Keywords
Acute kidney injury, continuous renal replacement therapy, mortality, children
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References
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