Article Sidebar

PDF
Issue: Vol. 563 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v563i1.18879
Date Published: 15/09/2026
Views 0
Downloads 0
How to Cite
Đặng, Q. B., Phạm, T. T. T., & Nguyễn Đ. T. (2026). IN-HOSPITAL MORTALITY IN VERY PRETERM NEONATES AT CHILDREN’S HOSPITAL 1 AND ASSOCIATED FACTORS: A LONGITUDINAL FOLLOW-UP STUDY. Vietnam Medical Journal, 563(1). https://doi.org/10.51298/vmj.v563i1.18879

IN-HOSPITAL MORTALITY IN VERY PRETERM NEONATES AT CHILDREN’S HOSPITAL 1 AND ASSOCIATED FACTORS: A LONGITUDINAL FOLLOW-UP STUDY

Quốc Bửu Đặng1, Thị Thanh Tâm Phạm1, Đức Toàn Nguyễn1,2,
1 Bệnh viện Nhi Đồng 1
2 Đại học Y khoa Phạm Ngọc Thạch

Main Article Content

Abstract

Objective: To identify factors associated with in-hospital mortality among preterm infants <32 weeks’ gestation treated in the Neonatal Intensive Care Unit (NICU), Children’s Hospital 1.


Methods: A longitudinal follow-up study (08/2024–10/2025) including 124 preterm infants <32 weeks’ gestation. The outcome was in-hospital mortality. Independent factors were analyzed using multivariable logistic regression, reporting odds ratios (ORs) and 95% confidence intervals (CIs).


Results: Overall in-hospital mortality was 20.2% (25/124). Multivariable logistic regression identified three independent factors associated with mortality: gestational age <28 weeks (OR=6.58; 95% CI 1.84–23.50; p=0.004), use of invasive high-frequency oscillatory ventilation (HFOV) (OR=22.69; 95% CI 5.71–90.12; p<0.001), and culture-positive bloodstream infection (OR=5.04; 95% CI 1.07–23.69; p=0.040).


Conclusions: Among preterm infants <32 weeks’ gestation, gestational age <28 weeks, invasive HFOV, and culture-positive bloodstream infection were independently associated with in-hospital mortality. These factors may support early risk stratification to prioritize monitoring and interventions to reduce mortality.

Keywords

Prematurity, <32 weeks’ gestation, in-hospital mortality, high-frequency oscillatory ventilation, bloodstream infection

Article Details

References

1. Boo NY, Chee SC, Neoh SH, et al. Ten-year trend of care practices, morbidities and survival of very preterm neonates in the Malaysian National Neonatal Registry: a retrospective cohort study. BMJ paediatrics open. 2021;5(1):e001149
2. Helenius K, Sjörs G, Shah PS, et al. Survival in Very Preterm Infants: An International Comparison of 10 National Neonatal Networks. Pediatrics. 2017;140(6)
3. Konzett K, Riedl D, Blassnig-Ezeh A, et al. Outcome in very preterm infants: a population-based study from a regional center in Austria. Frontiers in Pediatrics. 2024;12.
4. Ohuma EO, Moller A-B, Bradley E, et al. National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis. The Lancet. 2023;402(10409):1261-71
5. Oladapo OT, Vogel JP, Piaggio G, et al. Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries. The New England journal of medicine. 2020;383(26):2514-25
6. Shah J, Jefferies AL, Yoon EW, et al. Risk Factors and Outcomes of Late-Onset Bacterial Sepsis in Preterm Neonates Born at < 32 Weeks' Gestation. Am J Perinatol. 2015;32(7):675-82.
7. Stoll BJ, Hansen NI, Bell EF, et al. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA. 2015;314(10):1039-51
8. Thatrimontrichai A, Phatigomet M, Maneenil G, et al. Risk Factors for Mortality or Major Morbidities of Very Preterm Infants: A Study from Thailand. Am J Perinatol. 2023;41(10):1379-87.