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Issue: Vol. 563 No. 2 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v563i2.18959
Date Published: 05/10/2026
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Nguyễn, T. M. H., Lâm, V. N., & Trần, T. V. (2026). INVESTIGATION OF THE ASSOCIATION BETWEEN SERUM C-REACTIVE PROTEIN DYNAMICS AND THE DEVELOPMENT OF SEPTIC SHOCK AND THE REQUIREMENT FOR INVASIVE MECHANICAL VENTILATION IN HOSPITALIZED PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA. Vietnam Medical Journal, 563(2). https://doi.org/10.51298/vmj.v563i2.18959

INVESTIGATION OF THE ASSOCIATION BETWEEN SERUM C-REACTIVE PROTEIN DYNAMICS AND THE DEVELOPMENT OF SEPTIC SHOCK AND THE REQUIREMENT FOR INVASIVE MECHANICAL VENTILATION IN HOSPITALIZED PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

Thị Mỹ Huyền Nguyễn1, Vĩnh Niên Lâm1, Thành Vinh Trần2,
1 Đại học Y Dược TPHCM
2 Bệnh viện Chợ Rẫy

Main Article Content

Abstract

Objective: To investigate the prognostic significance of the relative change in serum C-reactive protein (CRP) between day 1 and day 3 for predicting the development of septic shock and the requirement for invasive mechanical ventilation (IMV) in hospitalized patients with community-acquired pneumonia (CAP), and to determine the optimal cut off values of ΔCRP % for these adverse outcomes.


Materials and methods: A prospective observational cohort study was conducted on 128 adult inpatients (≥18 years) with CAP admitted to Cho Ray Hospital from October 2024 to March 2025. Serum CRP concentrations were quantified on days 1 and 3 using a latex-enhanced immunoturbidimetric assay.


Results: Among 128 patients, 71.1 % were aged over 65 years. The incidence of septic shock was 18.0 %, and 21.2 % required IMV. The early CRP dynamics (ΔCRP%) between day 1 and day 3 were significantly associated with both complications. An increase in CRP >16.8% from day 1 to day 3 predicted the development of septic shock (AUC = 0.90, sensitivity 78.3%, specificity 90.5%), whereas a decrease in CRP <41.1% from day 1 to day 3 predicted the requirement for invasive mechanical ventilation (AUC = 0.78, sensitivity 92.9%, specificity 54.0%). Conclusion: Early CRP dynamics (ΔCRP%) between day 1 and day 3 were identified as an independent prognostic marker for the development of septic shock and the requirement for invasive mechanical ventilation in hospitalized patients with community-acquired pneumonia. Among these outcomes, CRP kinetics demonstrated outstanding prognostic accuracy in predicting septic shock.

Keywords

Community-acquired pneumonia, C-reactive protein, ΔCRP% (CRP dynamics), prognostic marker for septic shock, requirement for invasive mechanical ventilation

Article Details

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