CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN TÍNH CHẤT VI CẦU XỐP ĐIỀU CHẾ BẰNG PHƯƠNG PHÁP BỐC HƠI DUNG MÔI: MỘT NGHIÊN CỨU THEO THIẾT KẾ THỰC NGHIỆM

Abstract

Objective: Evaluate the potential simultaneous effect of critical formulation and process parameters on the particle mean size, encapsulation efficiency, sphericity, and porosity of the microspheres. Subjects and methods: Ethyl cellulose-based microspheres containing metronidazole were prepared by emulsification - solvent evaporation method. The experimental design was performed using the Box-Behnken model. Results: The encapsulation efficiency was influenced by polymer concentration and homogenization speed through an inverse rule. Formulation process with optimized conditions was established to produce microspheres with the sphericity of  0.90 ± 0.08, encapsulation efficiency of 14.44 ± 0.59 (%), particle mean size 153.14 ± 18.53 µm, and porosity 11.00 ± 1.74 mm³/g. Conclusion: The effect model of formulation and process parameters on microspheres’ properties was demonstrated, and the optimized preparation conditions were established. The study results supported the formulation process control to produce the porous microsphere. Thereby, researchers could estimate the proper conditions to achieve the porous microsphere with the desired property.