COMPARISON OF RECOVERY QUALITY BETWEEN DESFLURANE AND SEVOFLURANE IN PATIENTS UNDERGOING PERCUTANEOUS NEPHROLITHOTOMY AT TAM ANH GENERAL HOSPITAL IN 2026
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Abstract
Objective: To compare the recovery profiles of Desflurane and Sevoflurane in patients undergoing percutaneous nephrolithotomy (PCNL) under general anesthesia at Tam Anh General Hospital in 2026.
Methods: A randomized controlled clinical trial was conducted on 30 ASA I-III patients undergoing PCNL. Patients were randomly assigned into two groups: the Desflurane group (D, n = 15) and the Sevoflurane group (S, n = 15). The evaluated outcomes included time to achieve target minimum alveolar concentration (MAC), recovery MAC time, emergence time, extubation time, time to reach an Aldrete score > 9, and postoperative adverse events.
Results: The two groups were comparable in terms of age, sex, body mass index, duration of surgery, duration of anesthesia, and anesthetic drug consumption (p > 0.05). The time to achieve target MAC was significantly shorter in group D than in group S (59.3 ± 6.3 vs. 68.7 ± 7.2 seconds, p < 0.001). Recovery MAC time was also significantly shorter in group D (225.1 ± 60.5 vs. 330.6 ± 52.1 seconds, p < 0.001). Emergence time, extubation time, and time to achieve an Aldrete score > 9 were significantly shorter in group D compared with group S (6.4 ± 0.9 vs. 9.8 ± 1.5 minutes; 7.8 ± 0.9 vs. 11.8 ± 1.7 minutes; and 15.3 ± 1.8 vs. 22.1 ± 1.6 minutes, respectively; p < 0.001). Only one case of postoperative nausea was recorded in the Sevoflurane group, with no significant difference in adverse events between groups.
Conclusions: Desflurane provided faster induction and recovery from anesthesia than Sevoflurane, resulting in shorter emergence time, earlier tracheal extubation, and faster achievement of discharge criteria from the post-anesthesia care unit while maintaining a comparable safety profile. These findings support the use of Desflurane as an effective anesthetic agent in enhanced recovery after surgery (ERAS) protocols for patients undergoing PCNL.
Keywords
Desflurane, Sevoflurane, recovery profile, general anesthesia, percutaneous nephrolithotomy, enhanced recovery after surgery
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References
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