ĐẶC ĐIỂM LÂM SÀNG VÀ CÁC YẾU TỐ TIÊN ĐOÁN ĐÁP ỨNG ĐIỀU TRỊ ĐAU ĐẦU MIGRAINE TẠI BỆNH VIỆN ĐA KHOA TÂM ANH THÀNH PHỐ HỒ CHÍ MINH

Abstract

Background: Migraine is a common primary headache disorder that significantly affects quality of life and work productivity. Identifying clinical features and factors associated with treatment response is essential for optimizing preventive therapy.

Objectives: To describe demographic and clinical characteristics, comorbid conditions, and the effectiveness of preventive migraine treatment; to examine the associations between comorbidities and these factors; and to identify predictors of response to preventive therapy in patients with migraine at Tam Anh General Hospital, Ho Chi Minh City.

Results: The mean age was 38 ± 17 years, with a female predominance (79.4%). Unilateral headache (59.1%), pulsating pain (49.4%), and moderate intensity (65.9%) were the most common clinical features. Nausea was the most frequent associated symptom (53.3%). Sleep disorders (23.3%) and anxiety disorders (15.1%) were the most common comorbidities. Topiramate was the most frequently prescribed preventive medication (72.9%). Overall, 87.3% of patients achieved fair-to-good treatment response. Flunarizine demonstrated the highest rate of good/fair response (72.0%). Comorbid conditions were significantly associated with severe pain intensity, atypical pain characteristics, and the presence of sensory symptoms. Multivariate logistic regression identified depression (OR = 0.07), anxiety (OR = 0.36), nausea, vomiting, photophobia, and phonophobia as independent predictors of poor treatment response.

Conclusion: Migraine exhibits heterogeneous clinical manifestations and is frequently associated with psychiatric comorbidities. These comorbidities may substantially affect the response to preventive therapy and should therefore be carefully evaluated and comprehensively managed in clinical practice.