EFFICACY OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON MOTOR SYMPTOMS IN PATIENTS WITH PARKINSON’S DISEASE AT TAM ANH GENERAL HOSPITAL IN 2025
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Abstract
Parkinson’s disease is a neurodegenerative disorder characterized by both motor and non-motor symptoms. The prevalence of Parkinson’s disease increases with age, affecting approximately 1% of the population over 60 years old. Since the 1960s, substantial advances have highlighted multiple mechanisms contributing to the pathophysiology of movement disorders, including dopaminergic neurotransmitter depletion, alterations in basal ganglia–cortical loop networks, and cortical plasticity. Repetitive transcranial magnetic stimulation (rTMS) has emerged as an important modality in the multimodal management of patients with Parkinson’s disease. At Tam Anh General Hospital, we conducted a study on 45 patients diagnosed with Parkinson’s disease who received treatment from June 2025 to November 2025. Outcomes were assessed using two scales: the UPDRS III score and the Schwab and England Activities of Daily Living scale. In our study, patients treated with rTMS demonstrated improvements in both motor symptoms and activities of daily living.
Keywords
Parkinson’s disease, repetitive transcranial magnetic stimulation
Article Details
References
2. Jankovic J. Parkinson’s disease: clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry. 2008;79(4):368-376. doi:10.1136/jnnp.2007.131045
3. Smith Y, Wichmann T, Factor SA, DeLong MR. Parkinson’s Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa. Neuropsychopharmacol. 2012;37(1):213-246. doi:10.1038/npp.2011.212
4. Pascual-Leone A, Valls-Solé J, Brasil-Neto JP, Cammarota A, Grafman J, Hallett M. Akinesia in Parkinson’s disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation. Neurology. 1994;44(5):892-898. doi:10.1212/wnl.44.5.892
5. Lefaucheur JP, André-Obadia N, Antal A, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014;125(11):2150-2206. doi:10.1016/j.clinph.2014.05.021
6. Pringsheim T, Jette N, Frolkis A, Steeves TDL. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord. 2014;29(13):1583-1590. doi:10.1002/mds.25945
7. Elahi B, Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function--systematic review of controlled clinical trials. Mov Disord. 2009;24(3):357-363. doi:10.1002/mds.22364
8. Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 - The Lancet Neurology. Accessed April 3, 2026. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30295-3/fulltext
9. Benninger DH, Berman BD, Houdayer E, et al. Intermittent theta-burst transcranial magnetic stimulation for treatment of Parkinson disease. Neurology. 2011;76(7):601-609. doi:10.1212/WNL.0b013e31820ce6bb
10. Schrag A, Sampaio C, Counsell N, Poewe W. Minimal clinically important change on the unified Parkinson’s disease rating scale. Mov Disord Off J Mov Disord Soc. 2006;21(8):1200-1207. doi:10.1002/mds.20914
11. Shukla AW, Shuster JJ, Chung JW, et al. Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy in Parkinson Disease: A Meta-Analysis. PM R. 2016;8(4):356-366. doi:10.1016/j.pmrj.2015.08.009
12. Benninger DH, Iseki K, Kranick S, Luckenbaugh DA, Houdayer E, Hallett M. Controlled study of 50-Hz repetitive transcranial magnetic stimulation for the treatment of Parkinson disease. Neurorehabil Neural Repair. 2012;26(9):1096-1105. doi:10.1177/1545968312445636.