PREVALENCE AND GENOTYPE DISTRIBUTION OF HIGH-RISK HUMAN PAPILLOMAVIRUS IN CERVICAL SAMPLES AT TAM ANH HOSPITAL IN 2025
Main Article Content
Abstract
Background: Cervical cancer is strongly associated with persistent high-risk Human Papillomavirus (HR-HPV) infection. Genotype distribution varies by geography, population, and screening setting.
Objective: To determine HR-HPV prevalence and genotype distribution among women tested at Tam Anh General Hospital, including age-specific patterns and coinfection.
Methods: This retrospective cross-sectional study included 6,606 cervical specimens collected from January 1 to December 31, 2025. Real-time PCR testing was performed on the Cobas 5800 and Alinity m platforms. Proportions were reported with 95% confidence intervals (95% CI), and age-group differences were assessed using the Chi-square test.
Results: HR-HPV was detected in 928/6,606 samples, corresponding to 14.05% (95% CI: 13.23–14.91). HPV16, HPV18, and other HR-HPV were detected in 2.44%, 1.39%, and 11.43% of all samples, respectively. Prevalence was highest in women aged <30 years (16.87%), followed by those aged ≥50 years (15.83%); the difference was statistically significant (χ² = 17.24; df = 3; p < 0.001). Coinfection with at least two genotype groups occurred in 8.08% of positive cases.
Conclusion: HR-HPV prevalence was 14.05%. Non-HPV16/18 HR-HPV predominated, with higher prevalence among women aged <30 and ≥50 years.
Keywords
High-risk HPV infection, HPV16, HPV18, HR-HPV, Cervical cancer
Article Details
References
2. Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518-527. doi:10.1056/NEJMoa021641.
3. Vũ Duy Thái, Nguyễn Thị Thu Hà, Đỗ Minh Hương, Hà Thị Tuyết Mai, Phí Thị Minh Phương, Trần Thị Bích Phượng, et al. Thực trạng nhiễm HPV nhóm nguy cơ cao ở phụ nữ đến khám tại Bệnh viện Đa khoa Quốc tế Vinmec Times City. Vietnam Journal of Community Medicine. 2026;67(1):120-125. doi:10.52163/yhc.v67i1.4156.
4. Nguyễn Duy Ánh. Nghiên cứu tỷ lệ mắc HPV và một số yếu tố liên quan ở phụ nữ trong độ tuổi sinh sản ở Hà Nội. Tạp chí Y học Việt Nam. 2022;512(1). doi:10.51298/vmj.v512i1.2218.
5. Pham AH, Ha TH, Le TQ, Nguyen DQ, Vo TM. Prevalence of high-risk HPV infection in community women at Ho Chi Minh City in 2024: a cross-sectional study with self-collect sampling. Int J Womens Health. 2025;17:1673-1679. doi:10.2147/IJWH.S519586.
6. Nguyễn Thu Hằng, Hà Hải Bằng, Đào Ngọc Tuấn, Nguyễn Kim Huệ, Vi Huyền Nhung, Chu Thị Hồng Quyên. Khảo sát tình hình nhiễm Human Papillomavirus và sự phân bố các type nguy cơ cao ở phụ nữ đến khám phụ khoa tại Bệnh viện A Thái Nguyên. Journal of Military Pharmaco-medicine. 2025;50(1):46-52. doi:10.56535/jmpm.v50i1.944.
7. Yu YQ, Hao JQ, Mendez M, Mohamed SB, Fu SL, Zhao FH, Qiao YL. The prevalence of cervical HPV infection and genotype distribution in 856,535 Chinese women with normal and abnormal cervical lesions: a systematic review. J Cytol. 2022;39(4):137-147. doi:10.4103/joc.joc_42_22.