ĐÁNH GIÁ MỘT SỐ BIẾN CHỨNG VÀ TÁC DỤNG KHÔNG MONG MUỐN DO DÙNG NICARDIPIN ĐỂ KIỂM SOÁT HUYẾT ÁP Ở BỆNH NHÂN TIỀN SẢN GIẬT GÂY MÊ NỘI KHÍ QUẢN MỔ LẤY THAI

Abstract

Objectives:. To compare the complications and some side effects of intervention group with nicardipine injection before tracheal intubation versus control group in blood pressure control. Method: Randomized controlled trial in pre-eclampsia patients with stage 2 hypertension having indication of endotracheal intubation anesthesia for cesarean section in National Hospital for Obstetrics and Gynecology from April 2019 to September 2019. Results: Intervention group with nicardipine had increasing pulse rate from 86.8 ± 7.6 bpm to 102.7 ± 9.8 bpm at the time of 1 minute after injecting nicardipine (/phút tại thời điểm 1 phút sau tiêm Nicardipin (about 18%) and reached up to 106.5 ± 10.0 bpm (about 19%) at the time of intubation, then decreased to safety level (below 100 bpm). Other side effects such as nausea and vomiting, headaches, oliguria, hemorrhage… in 2 groups were the same. Conclusions: Using nicardipine could cause higher pulse rate but still be safe for controlling blood pressure in endotracheal intubation anesthesia for pre-eclampsia patients required cesarean section. The other complications as well as the effects on the fetus when using nicardipine were the same in 2 groups.