MỐI LIÊN QUAN GIỮA TỶ LỆ MÔ ĐỆM/U VỚI TÌNH TRẠNG DI CĂN HẠCH Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TUYẾN DẠ DÀY

Abstract

Objective: To analyze the association between the tumor-stroma ratio (TSR) on histopathological slides and lymph node metastasis in patients with gastric adenocarcinoma undergoing radical surgery.

Subjects and methods: A retrospective cross-sectional study of 72 patients with gastric adenocarcinoma who underwent radical gastrectomy with lymph node dissection at K Hospital, Tan Trieu campus (1/2025–6/2026). TSR was assessed on H&E slides of the invasive area and classified into stroma-poor (stroma ≤50%) and stroma-rich (>50%) groups. The association with lymph node metastasis was analyzed by multivariable logistic regression adjusted for pT and lymphovascular invasion.

Results: Mean age was 59.9 ± 10.3 years; 68.1% were male. Lymph node metastasis was present in 56.9% and stroma-rich TSR in 41.7%. The stroma-rich group had a higher rate of nodal metastasis (80.0% vs 40.5%; p=0.002) and a higher rate of pT3–pT4 (p=0.036). After adjustment, stroma-rich TSR was independently associated with lymph node metastasis (aOR 4.68; 95% CI: 1.32–16.64; p=0.017), together with pT3–pT4 (aOR 8.95).

Conclusion: Stroma-rich TSR was associated with lymph node metastasis in patients with gastric adenocarcinoma, and this association remained after adjustment for depth of invasion and lymphovascular invasion.