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Issue: Vol. 565 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v565i1.19211
Date Published: 03/11/2026
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How to Cite
Lưu, N. T., Phan, H. H., Đậu, L. N., & Lâm, V. H. (2026). A PRELIMINARY EVALUATION OF THE EFFECT OF ORAL L-ARGININE, L-GLUTAMINE, AND L-LEUCINE SUPPLEMENTATION ON WOUND HEALING IN MALNOURISHED PATIENTS WITH MODERATE-TO-SEVERE DIABETIC FOOT ULCERS. Vietnam Medical Journal, 565(1). https://doi.org/10.51298/vmj.v565i1.19211

A PRELIMINARY EVALUATION OF THE EFFECT OF ORAL L-ARGININE, L-GLUTAMINE, AND L-LEUCINE SUPPLEMENTATION ON WOUND HEALING IN MALNOURISHED PATIENTS WITH MODERATE-TO-SEVERE DIABETIC FOOT ULCERS

Ngân Tâm Lưu1, , Hữu Hên Phan1, Ly Na Đậu1, Văn Hoàng Lâm2
1 Bệnh viện Chợ Rẫy
2 Bệnh viện Đa khoa Tâm Anh

Main Article Content

Abstract

Objective: This study evaluated the clinical wound-healing outcomes of oral supplementation with this amino acid triad over 4 weeks.


Methods: A randomized, double-blind, controlled interventional study was conducted in 44 patients with moderate-to-severe DFU and malnutrition at Cho Ray Hospital (October 2023-December 2024).


Results: Ulcer area and depth improved over time in both groups (p<0.05); depth improvement was more marked in the intervention group (p<0.001 vs p<0.05 in controls). The depth-based healing rate after the first week was twice as high in the intervention group (0.35 ± 0.32 cm/week) as in controls (0.17 ± 0.25 cm/week; p<0.05). Tunnel size decreased significantly in the intervention group (p<0.001) but not in controls. Among patients with serum albumin <3.5 g/dL, the percentage of area healing at week 2 was nearly double in the intervention group (32.55%) versus controls (16.52%; p<0.05). The intervention was safe and well tolerated.


Conclusion: Oral supplementation with the L-arginine, L-glutamine and L-leucine triad contributes to DFU healing, most evidently during the first two weeks of intervention and in patients with low serum albumin.

Keywords

Diabetic foot ulcer, L-arginine, L-glutamine, L-leucine, wound healing, malnutrition

Article Details

References

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