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Issue: Vol. 565 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v565i1.19247
Date Published: 03/11/2026
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How to Cite
Ngô, V. N. M., & Đinh, V. H. (2026). ASSOCIATION OF OPRM1 rs1799971 AND DRD2 rs1800497 VARIANTS WITH SUBCORTICAL GRAY MATTER AND CORPUS CALLOSUM VOLUMES IN MEN WITH CHRONIC ALCOHOL DEPENDENCE. Vietnam Medical Journal, 565(1). https://doi.org/10.51298/vmj.v565i1.19247

ASSOCIATION OF OPRM1 rs1799971 AND DRD2 rs1800497 VARIANTS WITH SUBCORTICAL GRAY MATTER AND CORPUS CALLOSUM VOLUMES IN MEN WITH CHRONIC ALCOHOL DEPENDENCE

Văn Nhật Minh Ngô1, , Việt Hùng Đinh1
1 Học viện Quân y

Main Article Content

Abstract

Objective: To evaluate subcortical gray matter and corpus callosum volumes and their associations with OPRM1 rs1799971 and DRD2 rs1800497 in men with chronic alcohol dependence.


Subjects and Methods: A case-control study included 92 patients and 80 male controls at Military Hospital 103 from November 2023 to April 2026. Volumes were quantified on 3D T1 MRI using FreeSurfer 7.4.1; genotypes were determined by PCR-RFLP. ANCOVA adjusted for age and intracranial volume; two-way ANCOVA assessed genotype and Group × Genotype effects.


Results: Patients had lower volumes in 9/10 indices. The largest effects were for total subcortical volume (partial η²=0.381), amygdala (0.351), and corpus callosum (0.316); caudate volume did not differ. OPRM1 rs1799971 showed no significant genotype or interaction effect. DRD2 rs1800497 showed genotype effects for the amygdala (p=0.042) and hippocampus (p=0.036); TT exceeded CT for amygdala volume (p=0.037) and CC for hippocampal volume (p=0.049). A Group × Genotype interaction was found for corpus callosum volume (p=0.021).


Conclusion: Chronic alcohol dependence was associated with reduced volumes in most subcortical gray matter structures and the corpus callosum. OPRM1 rs1799971 showed no genotype-based association; DRD2 rs1800497 was nominally associated with amygdala and hippocampal volumes and suggested an interaction for the corpus callosum, which requires confirmation in larger samples.

Keywords

chronic alcohol dependence, OPRM1 rs1799971, DRD2 rs1800497, subcortical nuclei, corpus callosum

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