RESEARCH ON IMMATURE GRANULOCYTES AND RED BLOOD CELL DISTRIBUTION IN PERIPHERAL BLOOD OF PATIENTS WITH SEPSIS
Main Article Content
Abstract
Background: Sepsis is a severe systemic infection presenting with life-threatening organ dysfunction, resulting from a loss of control in the body’s response to infection. Recently, the immature granulocyte (IG) index and red blood cell distribution (RDW) have been extensively studied in assessing patients’ response to inflammation and infection.
Objectives: 1. To analyze peripheral blood cell indices in patients with sepsis. 2. To determine the cutoff values of IG and RDW in predicting sepsis.
Study Design: A descriptive cross-sectional study with controls.
Study Location and Time: Department of Hematology and Blood Transfusion, Clinical Departments - Hue University of Medicine and Pharmacy Hospital, from February 2025 to May 2026.
Study Subjects: Patients with sepsis; control group: Patients with infections and healthy individuals.
Results: The mean values of white blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LYM), IG, and RDW in the septic group, infectious group and the healthy group were (16.65 G/L, 14.44 G/L, 1.26 G/L, 0.45 G/L, 14.34%), (11.67 G/L, 9.20 G/L, 1.43 G/L, 0.10 G/L, 13.36%), and (6.98 G/L, 3.84 G/L, 2.30 G/L, 0.02 G/L, 12.39%), respectively; IG and RDW indices were statistically significantly higher in the septic/infectious group compared to the other two groups (p < 0.05). The cutoff points for IG and RDW indices predicting sepsis with infectious group and healthy group were 0.075 G/L (p = 0.001), 13.55% (p = < 0.001) and 0.035 G/L (p < 0.001), 12.65% (p < 0.001), respectively.
Conclusion: Peripheral blood IG and RDW indices are valuable in predicting sepsis.
Keywords
Immature granulocytes, sepsis
Article Details
References
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