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Issue: Vol. 567 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v567i1.19280
Date Published: 05/11/2026
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Downloads 21
How to Cite
Lê, K. T., Nguyễn, N. M., Nguyễn, T. B. Ú., Trịnh, T. H. M., Nguyễn, T. M. L., Phạm, T. T. D., Lê, H. H., Bùi, L. T. N., & Hoàng, T. T. H. (2026). EVALUATION OF THE EFFECTIVENESS OF PERIPHERAL BLOOD STEM CELL PROCESSING AND CRYOPRESERVATION AT CHO RAY HOSPITAL. Vietnam Medical Journal, 567(1). https://doi.org/10.51298/vmj.v567i1.19280

EVALUATION OF THE EFFECTIVENESS OF PERIPHERAL BLOOD STEM CELL PROCESSING AND CRYOPRESERVATION AT CHO RAY HOSPITAL

Kim Thảo Lê1, , Ngọc Mai Nguyễn1, Thị Bé Út Nguyễn1, Thị Hoa Mai Trịnh1, Thị Mỹ Linh Nguyễn1, Thị Thuỳ Dung Phạm1, Hoàng Hưng Lê1, Lê Thảo Như Bùi1, Thị Thuý Hà Hoàng1
1 Bệnh viện Chợ Rẫy

Main Article Content

Abstract

Objective: To evaluate the effectiveness of the processing and cryopreservation procedure for peripheral blood stem cells (PBSCs) at Cho Ray Hospital during 2024–2025.


Methods: A retrospective cross-sectional descriptive study was conducted on 35 PBSC units collected, processed, cryopreserved, and used for hematopoietic stem cell transplantation at Cho Ray Hospital from January 2024 to December 2025.


Main findings: The mean processing-to-storage time was 3.3 ± 0.47 hours; the mean storage bag volume was 125.4 ± 13.54 mL; the mean cell concentration was 2.0 ± 0.9 × 10⁸ cells/mL; and the median storage duration was 44 days. After thawing, both the absolute number of viable CD34⁺ cells and the percentage of viable CD34⁺ cells decreased significantly compared with pre-storage values (p < 0.001). The median recovery rate of viable CD34⁺ cells was 84.89% (IQR: 17.38%), while the median preservation rate of viable CD34⁺ cells was 97.92% (IQR: 4.63%). No processing-related factor showed an independent statistically significant association with the recovery rate of viable CD34⁺ cells after thawing.


Conclusions: The PBSC processing and cryopreservation procedure at Cho Ray Hospital demonstrated good cell preservation efficiency, maintaining high recovery and viability of CD34⁺ cells after thawing.

Keywords

Peripheral blood stem cells, PBSC, CD34⁺, cryopreservation, recovery rate

Article Details

References

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