Article Sidebar

PDF
Issue: Vol. 567 No. 1 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v567i1.19285
Date Published: 05/11/2026
Views 31
Downloads 20
How to Cite
Đỗ, Q. L., Thân, T. L., Lê, X. T., Nguyễn, B. K., Trần, N. Q., & Nguyễn, H. T. (2026). COLLECTION EFFICIENCY OF PERIPHERAL BLOOD HEMATOPOIETIC STEM CELLS FOLLOWING APHERESIS AT THE STEM CELL BANK – NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION FROM 2022-2024. Vietnam Medical Journal, 567(1). https://doi.org/10.51298/vmj.v567i1.19285

COLLECTION EFFICIENCY OF PERIPHERAL BLOOD HEMATOPOIETIC STEM CELLS FOLLOWING APHERESIS AT THE STEM CELL BANK – NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION FROM 2022-2024

Quang Linh Đỗ1, , Thùy Linh Thân1, Xuân Thịnh Lê1, Bá Khanh Nguyễn1, Ngọc Quế Trần1, Hà Thanh Nguyễn1
1 Viện Huyết học – Truyền máu Trung ương

Main Article Content

Abstract

Objective: To evaluate the collection efficiency (CE) of hematopoietic stem cells from peripheral blood following apheresis at National Institute of Hematology and Blood Transfusion between 2022 and 2024.


Study design: A descriptive study of all apheresis procedures performed at Stem Cell Bank – National Institute of Hematology and Blood Transfusion, from January 2022 to December 2024.


Study Subjects: 195 apheresis procedures performed on donors and patients to collect peripheral blood hematopoietic stem cells using automated apheresis systems.


Results: The study included 110 allogeneic donors and 85 patients. The mean CE was 47.75%. The average cell dose per single apheresis procedure was 7.71 x 10⁶ CD34+ cells/kg for the patient group and 9.17 x 10⁶ CD34+ cells/kg for the donor group. Multivariate analysis indicated that the pre-apheresis CD34+ cell count and the number of total blood volumes (TBV) processed were inversely linearly correlated with CE.


Conclusion: Peripheral blood stem cell apheresis at the unit achieved stable CE, with a high rate of reaching the target cell dose within the first procedure.

Keywords

Peripheral blood stem cell apheresis, CD34 collection efficiency

Article Details

References

1. Khanh BQ, Binh VTT, Thanh NH, Huong DPT, Thuy DT, Ha NK, et al. Forging international collaboration and alliances to establish the largest transplant center in the north of Vietnam. Seminars in Hematology. 2023;60(4):243-50.
2. Giralt S, Stadtmauer E, Harousseau J-L, Palumbo A, Bensinger W, Comenzo R, et al. International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100). Leukemia. 2009;23(10):1904-12.
3. Lê Xuân Thịnh, Trần Ngọc Quế, Nguyễn Bá Khanh, Võ Thị Thanh Bình, Bạch Quốc Khánh. Nghiên cứu đặc điểm tế bào máu của người hiến và bệnh nhân được gạn tách tế bào gốc máu ngoại vi tại Viện Huyết học - Truyền máu TW giai đoạn 2015-2017. Tạp chí Y học Việt Nam. 2018;467:900-7.
4. Neyrinck MM, Vrielink H, Education JTFf, Certification. Calculations in apheresis. Journal of clinical apheresis. 2015;30(1):38-42.
5. Miller A, Davies J, Young K, Eckman E, Lo MY, Erskine H, et al. The effect of increased collect pump rate on collection efficiency in hematopoietic progenitor cell collection by apheresis in allogeneic adult donors—A single center analysis. Transfusion. 2023;63(10):1926-36.
6. Kondo T, Fujii N, Fujii K, Sumii Y, Urata T, Kimura M, et al. Low hematocrit reduces the efficiency of CD34+ cell collection when using the Spectra Optia continuous mononuclear cell collection procedure. Transfusion. 2022;62(5):1065-72.
7. Heuft H, Dubiel M, Kingreen D, Oertel J, De Reys S, Rick O, et al. Automated collection of peripheral blood stem cells with the COBE spectra for autotransplantation. Vox sanguinis. 2000;79(2):94-9.
8. Tiwari AK, Pandey P, Subbaraman H, Bhargava R, Rawat G, Madiraju S, et al. Autologous peripheral blood stem cell harvest: Collection efficiency and factors affecting it. Asian Journal of Transfusion Science. 2016;10(1):93-7.
9. Özkan SG, Kimiaei A, Safaei S, Ercan T, Sönmezoğlu M, Demirel GY, et al. Prediction of CD34+ hematopoietic stem cells in healthy allogeneic stem cell donors on the Optia cell separator based on CE2: Which formula is more correlated with actual CD34+? Transfusion. 2024;64(10):1959-67.
10. Verlinden A, Van de Velde A, Verpooten GA, Janssen van Doorn K. Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions. Journal of clinical apheresis. 2013;28(6):404-10.