CHANGES IN CERTAIN HEMATOLOGICAL AND BLOOD BIOCHEMICAL PARAMETERS AMONG PLATELET DONORS USING THE TRIMA ACCEL SYSTEM AT THE NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION IN 2025.
Main Article Content
Abstract
Objective: To describe changes in certain hematological and blood biochemical parameters before and after apheresis in platelet donors using the Trima Accel system, and to analyze factors associated with the apheresis process.
Subjects and Methods: A prospective, pre-post comparison study was conducted at the National Institute of Hematology and Blood Transfusion between 4-12/2025, involving 100 donors who met the eligibility criteria set forth in Circular 26/2013/TT-BYT and underwent the Trima Accel apheresis procedure. Hematological parameters (WBC, RBC, HGB, HCT, PLT) and biochemical markers (total protein, albumin, total calcium, ionized calcium) were assessed before and after the procedure, and relevant associated factors were analyzed. Data was processed using SPSS 20.0.
Results: Following apheresis, mean PLT decreased by 67.97 ± 21.20 × 109/L, WBC by 0.48 ± 0.61 × 109/L, Protein by 3.55 ± 3.12 g/L, albumin by 2.21 ± 1.54 g/L, and calcium by 0.027 ± 0.069 mmol/L (p < 0.001); RBC, HGB, and HCT increased slightly (p < 0.001), while ionized calcium showed no statistically significant change (p > 0.05). Pre- and post- PLT counts were strongly positively correlated (r = 0.885; p < 0.001). Multivariate regression analysis revealed that gender, BMI, and pre- PLT count were independently associated with apheresis duration (p < 0.05).
Conclusion: Following platelet apheresis using the Trima Accel system, platelet count (PLT) decreased markedly; WBC, total protein, albumin, and total calcium levels showed slight decreases; RBC, HGB, and HCT showed slight increases; and changes in ionized calcium were not statistically significant. Pre- and post-donation PLT values were strongly positively correlated. Gender, BMI, and pre-donation PLT were independently associated with apheresis duration, whereas age and the number of prior platelet donations showed no statistically significant association.
Keywords
Platelet apheresis, Trima Accel, hematology, biochemistry
Article Details
References
2. Gil-Betancur A, Mantilla-Gutierrez CY, Cardona-Arias JA. Effect of plateletpheresis on total platelet count and mean platelet volume: a meta-analysis. J Evid Based Med. 2020;13(3):206–214. doi:10.1111/jebm.12403.
3. Syal N, Kukar N, Arora H, Kaur A, Handa A, Maharishi RN. Assessment of pre and post donation changes in hematological parameters and serum calcium and magnesium levels in plateletpheresis donors. J Family Med Prim Care. 2022;11(4):1489–1492. doi:10.4103/jfmpc.jfmpc_1409_21
4. Garg K, Kaur P, Bedi RK, Gupta S. Alteration in biochemical parameters during plateletpheresis in healthy donors: a compendious analysis. Transfus Clin Biol. 2021;28(3):239-245. doi:10.1016/j.tracli.2021.04.010
5. Arcot PJ, Kumar K, Coshic P, Andriyas V, Mehta V. A comparative study of five plateletpheresis machines in a tertiary care center of India. J Clin Apher. 2021;36(1):41-47. doi:10.1002/jca.21838
6. Gulia SP, Rattan A, Singh S, Gupta D. Evaluation of hematological parameters and platelet yield in voluntary blood donors by plateletpheresis. Int J Res Med Sci. 2024;12(6):1904-1908. doi:10.18203/2320-6012.ijrms20241294
7. Lê Phước Quang. Nghiên cứu sự biến đổi các chỉ số huyết học, hóa sinh ở người hiến tiểu cầu trên máy COM.TEC tại Bệnh viện Trung ương Huế. Tạp chí Y học Việt Nam. 2019;467:170
8. Terumo BCT. Trima Accel® operator’s manual. Lakewood (CO): Terumo BCT; 2019