THỰC TRẠNG HOẠT ĐỘNG BÁO CÁO PHẢN ỨNG CÓ HẠI CỦA THUỐC TẠI BỆNH VIỆN BẠCH MAI GIAI ĐOẠN 2013 – 2019

Abstract

Objective: To investigate the current practices regarding adverse drug reaction (ADR) reporting in Bach Mai Hospital during the period 2013 – 2019. Subjects and methods: Cross-sectional descriptive of ADR reports registered in The National Drug Information and Adverse Drug Reactions Monitoring Centre from 2013 to 2019. Result: There was a total of 2.102 ADR reports during the seven year period. The number of monthly ADR reports tended to decrease (α=-0.03), however, not significantly (p=0.587). Meanwhile, the number of monthly spontaneous ADR reports climbed slightly (α=0.013, p=0.656). The ADR per 1000 people rate was 2.13. The majority of ADR reporters were doctors (58%) and only 20.3% were made by pharmacists which increased accordingly active surveillance. There was a 62% good quality ADR reports and the mean point of whole time was 0.79. Antibiotics, antipsychotics drugs and contrast media were the most common related medications. The most frequently reported ADRs were associated with skin and subcutaneous tissue disorders such as rash erythematous, pruritus and rash. Conclusion: Result of this study showed that the number of ADR reports was higher in compare with others but still inadequate compared to the large scale and potential of the hospital. ADR monitoring, detection and reporting had been unsteady, and the involvement of clinical pharmacists was still limited. Therefore, more effective solutions should be taken to enhance ADR surveillance activities, particulary through clinical pharmacy interventions.