Article Sidebar

PDF
Date Published: 13/03/2022
Abstract Views: 691
Views PDF: 375
DOI: https://doi.org/10.51298/vmj.v510i2.1960
Issue
Vol. 510 No. 2 (2022)
Section
Các bài báo
How to Cite
Văn Bảo, N., & Mạnh Cường, L. . (2022). EVALUATION OF THE SUB-CHRONIC TOXICITY OF “BACH PHU THANG”. Vietnam Medical Journal, 510(2). https://doi.org/10.51298/vmj.v510i2.1960

EVALUATION OF THE SUB-CHRONIC TOXICITY OF “BACH PHU THANG”

Nguyễn Văn Bảo1, Lê Mạnh Cường2,
1 Vietnam University of Traditional Medicine
2 National Hospital of Traditional Medicine

Main Article Content

Abstract

Objectives: To evaluate the sub-chronic toxicity of "Bach phu thang" through oral administration in an animal experiment. Subjects and  methods: The sub-chronic toxicity study was conducted according to the guidelines of WHO in rats with oral doses of 11.4 g/kg/day and 22.8 g/kg/day for 4 consecutive weeks. Result: Oral administration of "Bach phuthang" had no effect on general condition, body weight, hematological and hepato-renal functions, or histopathological liver and kidney structures. Conclusion: "Bach phu thang" has no sub-chronic toxicity in experimental rats.

Article Details

Keywords

Bach phu thang, sub-chronic toxicity, rats

References

1. De Jong WH, Carraway JW, Geertsma RE. In vivo and in vitro testing for the biological safety evaluation of biomaterials and medical devices. Biocompatibility and Performance of Medical Devices. 2012;120-158.
2. Saganuwan SA. Toxicity studies of drugs and chemicals in animals: An overview. Bulgarian Journal of Veterinary Medicine. 2017;20(4):291-318.
3. Viện dược liệu. Cây thuốc và động vật làm thuốc, Nhà xuất bản Khoa học và Kỹ thuật, Hà Nội, 2007.
4. Đỗ Tất Lợi (2015). Những cây thuốc và vị thuốc Việt Nam. Nhà xuất bản Y học,Hà Nội.
5. World Health Organization. Working group on the safety and efficacy of herbal medicine, Report of regional office for the western pacific of the World Health Organization, 2000.
6. Nguyễn Thế Khánh, Phạm Tử Dương. Xét nghiệm sử dụng trong lâm sàng. Nhà xuất bản Y học, 2001.
7. Vũ Đình Vinh. Hướng dẫn sử dụng các xét nghiệm sinh hoá. Nhà xuất bản Y học, 2001;115-287.
8. Cha SB, Kim HS, Bae JS et al. A 13-week subchronic toxicity study of a Dioscorea Rhizome water extract in rats. Regulatory Toxicology and Pharmacology. 2021;120.