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Date Published: 15/04/2022
Abstract Views: 139
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DOI: https://doi.org/10.51298/vmj.v511i1.2077
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Vol. 511 No. 1 (2022)
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Các bài báo
How to Cite
Ngọc Khánh N. ., & Thị Thúy Lan D. . (2022). SOME FACTORS RELATED ON THE FALSE-POSITIVE RATE IN THE NEWBORN SCREENING PROGRAM FOR CONGENITAL HYPOTHYROIDISM AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL. Vietnam Medical Journal, 511(1). https://doi.org/10.51298/vmj.v511i1.2077

SOME FACTORS RELATED ON THE FALSE-POSITIVE RATE IN THE NEWBORN SCREENING PROGRAM FOR CONGENITAL HYPOTHYROIDISM AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL

Nguyễn Ngọc Khánh1,, Diệp Thị Thúy Lan2
1 Vietnam National Children's Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Objectives: Analysis of some factors related to the false-positive rate in the screening program for congenital hypothyroidism at the National Children's Hospital. Subjects and methods: The study on 159 children with heel blood TSH concentration 10 mUI/L. Results: The false-positive rate was 21.4%. Positive predictive values ​​at TSH levels ≥ 10 mUI/L, ≥ 18 mUI/L, ≥ 20 mUI/L, ≥ 30 mUI/L, ≥ 40 mUI/L were 78.6%, 80.8%, 81 , 7%, 84.9%, 86%, respectively. Associated factors such as: gestational age < 37 weeks had a false-positive rate 5.41 times higher than that of the group ≥37 weeks (OR=5.41; 95%CI: 1.23 – 24.76). Postpartum sampling time <48 hours had a false-positive rate 2.01 times higher than the group ≥ 48 hours (OR=2.01; 95%CI: 1.27 – 3.11). Conclusions: The false-positive rate in the study with TSH ≥ 10 mUI/L was acceptable with the newborn screening program. Postpartum sampling time ≥ 48 hours can limit false-positive rate.

Article Details

Keywords

Newborn screening, Congenital hypothyroidism, Related factors

References

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