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Date Published: 15/04/2022
Abstract Views: 216
Views PDF: 137
DOI: https://doi.org/10.51298/vmj.v511i1.2077
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Vol. 511 No. 1 (2022)
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Các bài báo
How to Cite
Ngọc Khánh N. ., & Thị Thúy Lan D. . (2022). SOME FACTORS RELATED ON THE FALSE-POSITIVE RATE IN THE NEWBORN SCREENING PROGRAM FOR CONGENITAL HYPOTHYROIDISM AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL. Vietnam Medical Journal, 511(1). https://doi.org/10.51298/vmj.v511i1.2077

SOME FACTORS RELATED ON THE FALSE-POSITIVE RATE IN THE NEWBORN SCREENING PROGRAM FOR CONGENITAL HYPOTHYROIDISM AT THE VIETNAM NATIONAL CHILDREN’S HOSPITAL

Nguyễn Ngọc Khánh1,, Diệp Thị Thúy Lan2
1 Vietnam National Children's Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Objectives: Analysis of some factors related to the false-positive rate in the screening program for congenital hypothyroidism at the National Children's Hospital. Subjects and methods: The study on 159 children with heel blood TSH concentration 10 mUI/L. Results: The false-positive rate was 21.4%. Positive predictive values ​​at TSH levels ≥ 10 mUI/L, ≥ 18 mUI/L, ≥ 20 mUI/L, ≥ 30 mUI/L, ≥ 40 mUI/L were 78.6%, 80.8%, 81 , 7%, 84.9%, 86%, respectively. Associated factors such as: gestational age < 37 weeks had a false-positive rate 5.41 times higher than that of the group ≥37 weeks (OR=5.41; 95%CI: 1.23 – 24.76). Postpartum sampling time <48 hours had a false-positive rate 2.01 times higher than the group ≥ 48 hours (OR=2.01; 95%CI: 1.27 – 3.11). Conclusions: The false-positive rate in the study with TSH ≥ 10 mUI/L was acceptable with the newborn screening program. Postpartum sampling time ≥ 48 hours can limit false-positive rate.

Article Details

Keywords

Newborn screening, Congenital hypothyroidism, Related factors

References

1. Büyükgebiz, A. (2013). Newborn Screening for Congenital Hypothyroidism. Journal of Clinical Research in Pediatric Endocrinology, 5(Suppl 1), 8–12.
2. Kopel, J. (2019). A global perspective on newborn congenital hypothyroidism screening. Proceedings (Baylor University. Medical Center), 33(1), 137–139.
3. Saleh, D., Lawrence, S., Geraghty, M., et al. (2016). Prediction of congenital hypothyroidism based on initial screening thyroid-stimulating-hormone. BMC Pediatrics, 16.
4. Lüders, A., Blankenstein, O., Brockow, et al. (2021). Neonatal Screening for Congenital Metabolic and Endocrine Disorders. Deutsches Ärzteblatt International, 118(7), 101–108.
5. Knowles, R. L., Oerton, J., Cheetham, T., et al. (2018). Newborn Screening for Primary Congenital Hypothyroidism: Estimating Test Performance at Different TSH Thresholds. The Journal of Clinical Endocrinology and Metabolism, 103(10), 3720–3728.
6. Lain, S., Trumpff, C., Grosse, S. D., Olivieri, A., et al (2017). Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? European journal of endocrinology, 177(5), D1–D12.
7. Rose, S. R., Brown, R. S., et al. (2006). Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics, 117(6), 2290–2303.
8. Natasha L Heather, José GB Derraik, Dianne Webster et al (2019), "The impact of demographic factors on newborn TSH levels and congenital hypothyroidism screening", Clinical Endocrinology, 91(3), tr. 456-463.