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STUDY CLINICAL CHARACTERISTICS AND SERUM PROCALCITONIN CONCENTRATION IN EARLY PERIOD NEONATAL INFECTIONS AT NINH THUAN PROVINCE GENERAL HOSPITAL
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Abstract
Introduction: Neonatal infection early period is one of the most common causes of neonatal deaths globally. Objective: Describe clinical and serum procalcitonin concentration in early period neonatal infections. Subjects and Methods: Longitudinal study on 39 infants from 1 to 7 days old, treated for neonatal infections at pediatrics department, Ninh Thuan province general hospital, from January to september 2021. Results: Clinical: Systemic: Pale yellow skin (12.8%), fever (12.8%), cyanosis (12.8%). The cardiac: heart rate ≥160 beats/minute (15.4%), CRT >3 seconds (7.7%). Respiratory: breathing rate ≥60 beats/minute (33.3%) and <20 beats/minute (12.8%), breathlessness (10.3%), apnoea (7.7%). Neurological: decreased reflexes (51.3%), poor muscle tone (30.8%), inflexibility (20.5%). Gastrointestinal: poor feeding/ give up sucking (38.5%), vomiting (30.8%), abdominal distention (12.8%). Median serum PCT concentration in the neonatal infection early period group (4.3 ng/ml) was higher than that in the uninfected group (p<0.05). The area under the curve was 0.96 (p<0.001) high or low PCT concentrations were able to identify neonatal infection early period with a cut-off 0.17 ng/ml with a sensitivity of 97% and a specificity of 86%. Conclusion: The degree of clinical manifestations is highly variable and PCT is very valuable in the diagnosis of neonatal infection early period.
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Keywords
Neonatal infections, Procalcitonin
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