THỰC TRẠNG NHIỄM VIRUS VIÊM GAN B Ở TRẺ SƠ SINH CỦA CÁC BÀ MẸ CÓ HBsAg (+) TẠI BỆNH VIỆN QUÂN Y 103

Abstract

Objectives: evaluate the status of hepatitis B virus infection in newborns of mothers with HBsAg (+) and the relationship between the appearance of HBV markers in cord blood with the presence of these markers in maternal blood. Subjects and methods: A cross‐sectional study. 120 newborns of mothers with HBsAg (+) were at the Obstetrics Department, 103 Military Hospital, from August 2021 to December 2021. Results: Among 120 newborns with HsAg (+), the percentage of HBV markers in cord blood of the children was: the rate of HBsAg (+) 60.8%, HBeAg (+) 13.3% and HBV DNA ( +) was 16.7%. In maternal blood, the rate of HBeAg (+) was 30.8%, HBV DNA ≥5 log 10 copies/mL was 25.0%, mean ALT and AST levels were 25.7 ± 11.3 and 29.3 ± 12.7 U/L respectively. The rate of HBsAg (+) in the group of mothers with HBeAg (+) was 91.9%, higher than the group of HBeAg (-) was 47.0%, the difference was statistically significant, p<0.01. In the group of mothers with HBV DNA levels ≥5 log 10 copies/mL, 80.0% of children had HBsAg (+), 54.4% higher than the group with HBV DNA <5 log 10 copies/mL. The difference was statistically significant, p<0.01. Conclusions: the rate of HBsAg (+) in cord blood of the newborns was 60.8%, the rate of HBeAg (+) was 13.3% and the rate of HBV DNA (+) was 16.7%. In maternal blood, HBeAg (+) and HBV DNA levels ≥ 5 log 10 copies/mL are factors that increase the risk of mother-to-child transmission of HBV.