ĐÁNH GIÁ ĐỘC TÍNH VÀ TÁC DỤNG BẢO VỆ GAN CỦA HAI CHẾ PHẨM TỪ ĐÔNG TRÙNG HẠ THẢO DO CÔNG TY TNHH LAVITE SẢN XUẤT

Abstract

Introduction: Cordyceps militaris is widely used in treatment and improving human health such as: Anti-cancer, immunomodulatory, antioxidant. Methods: To evaluate the irregular toxicity and hepatoprotective effects of Cordyceps-containing products manufactured by Lavite Co., Ltd., the study was conducted through the abnormal oral toxicity test on rat. Hepatoprotective effects on a long-term ethanol-induced rat liver injury model. Results: Both samples of The aqueous extract of Cordyceps Hector Ginseng (11.76-23.52 mL/kg of mouse weight/day equivalent to a dose of 50-100 mL/day) and Capsules 100% Hector Cordyceps (58.8-117.6 mg powder/kg body weight equivalent to dose 1-2 tablets/day) had no abnormal toxicity in test rats and had hepatoprotective effects, decreased plasma AST-ALT liver enzyme activity and decreased MDA content inhibiting hepatocyte lipid peroxidation in rat liver. Conclusion: Both samples can be used as a safe preparation with a hepatoprotective effect.