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Date Published: 21/04/2022
Abstract Views: 465
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DOI: https://doi.org/10.51298/vmj.v511i2.2151
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Vol. 511 No. 2 (2022)
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Các bài báo
How to Cite
Lê Huy, T. ., & Đình Anh, T. . (2022). EVALUATION OF TREATMENT RESULTS FOR STAGE IV NON-SMALL CELL LUNG CANCER WITH NAVELBIN METRONOMIC AT HANOI MEDICAL UNIVERSITY HOSPITAL. Vietnam Medical Journal, 511(2). https://doi.org/10.51298/vmj.v511i2.2151

EVALUATION OF TREATMENT RESULTS FOR STAGE IV NON-SMALL CELL LUNG CANCER WITH NAVELBIN METRONOMIC AT HANOI MEDICAL UNIVERSITY HOSPITAL

Trịnh Lê Huy1,2,, Trần Đình Anh2
1 Hanoi Medical University
2 Hanoi Medical University Hospital

Main Article Content

Abstract

Objective: To evaluate the treatment results of Navelbine metronomic in stage IV non-small cell lung cancer (NSCLC). Patients and methods: Retrospective, descriptive study on30stage IV non-small cell lung cancer patients treated with Navelbin metronomic regimen at the Department of Oncology and Palliative Care, Hanoi Medical University Hospital from January 2014 to November 2020. Results: The mean age was67 years old, ratio male/female=6:1. All of the patients have performance status (PS) 2-3, in which PS3 accounted for 60%. Among 30 patients, 5 patients (16.7%) received first-line treatment, and 25 patients (83.3%) received second-line treatment. Most of the patients had underlying medical conditions, in which hypertension accounted for the highest rate (43.3%). The response rate was 36.7%, the PS was a statistically significant predictor of response (P<0.05). Median progression-free survival (PFS) was 8 months with first-line treatment and 6 months with second-line treatment (P>0.05). The rate of toxicity was low, mainly at a mild level (grade 1/2), the most common side effect was anemia with a rate of 30%, no patients had grade 3/4.Conclusion: Navelbine metronomic was safe and effective in stage IV NSCLC patients with poor performance status (PS 2-3) and comorbidities.

Article Details

Keywords

non-small cell lung cancer, Navelbin, Metronomic

References

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