RECOVERY OF FILLER INDUCED TOTAL VISUAL LOSS: FIRST CASE OF VIETNAM AND LITERATURE REVIEW

Nguyễn Hồng Hà, Trần Thị Thanh Huyền, Dương Hồng Quân, Nguyễn Xuân Hiệp, Nguyễn Quốc Anh, Đồng Ngọc Minh, Nguyễn Đình Minh, Đào Xuân Hải, Lê Thanh Dũng

Main Article Content

Abstract

Introduction: With the global increase in the use ofinjectable hyaluronic acid (HA), more cases with serious complication are being reported. HA embolism leads to serious complications including blindness, eye and eyelid movement disorders, skin necrosis and cerebral embolism.However, there is a lack of robust clinical evidence regarding recovery vision due to embolisme of ophthalmic artery and central retinal artery. Patient and method: We present a case report of a patient who developed features of vascular involvement after one ml of HA filler injection in the nasal dorsum illegaly at Spa. The patient initially developedsevere pain and total vision loss in the right eye immediately by the time of injection. Result: She was managed emergency with multiple disciplinary therapy combined of general and local treatment including ocular massage, hyaluronidase intracutanous, retrobulbar injections and intra arterial thrombolysis for 2 periods consecutive of vision loss. Significantrecovery in the vision and skin, ophthalmic components occurred within 6 weeks. Conclusion: This case demonstrates that recovery of the vision, ischaemic ophthalmic and cutaneous due to embolism of central retinal artery could be accomplished using combined multiple disciplinary therapy and intra arterial thrombolysis injections of hyaluronidase.

Article Details

References

1. Kapoor KM, Kapoor P, Heydenrych I, Bertossi D.Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. Aesthetic Plast Surg. 2020 Jun; 44(3): 929-944. Epub 2019 Dec 10.
2. Fallacara A, Manfredini S, Durini E, Vertuani S. Hyaluronic Acid Fillers in Soft Tissue Regeneration. Facial Plast Surg. 2017;33(1):87-96.
3. International Society of Aesthetic Plastic Surgeons (ISAPS) International survey on aesthetic cosmetic procedures performedin 2018. ISAPS Global Survey Press Release. 3 Dec 2019
4. Beleznay K, Humphrey S, Carruthers JD, Carruthers A. Vascular compromise from soft tissue augmentation: experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol. 2014; 7(9):37–43.
5. DeLorenzi C. Complications of injectable fillers, part 2: vascular complications. Aesthet Surg J. 2014; 34(4):584–600.
6. Thanasarnaksorn W, Cotofana S, Rudolph C, Kraisak P, Chanasumon N, Suwanchinda A. Severe vision loss caused by cosmetic filler augmentation: Case series with review of cause and therapy. J Cosmet Dermatol.J Cosmet Dermatol. 2018;17(5):712-8.
7. Chen YC, Wu HM, Chen SJ, Lee HJ, Lirng JF, Lin CJ, Chang FC, Luo CB, Guo WY. Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. Facial Plast Surg. 2018 Jun;34(3):325-9.
8. Zhang LX, Lai LY, Zhou GW, Liang LM, Zhou YC, Bai XY, Dai Q, Yu YT, Tang WQ, Chen ML. Evaluation of Intraarterial Thrombolysis in Treatment of Cosmetic Facial Filler-Related Ophthalmic Artery Occlusion. Plast Reconstr Surg. 2020 Jan; 145(1):42e-50e.