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Date Published: 25/04/2022
Abstract Views: 275
Views PDF: 189
DOI: https://doi.org/10.51298/vmj.v512i1.2212
Issue
Vol. 512 No. 1 (2022)
Section
Các bài báo
How to Cite
Thế Long, B. ., Văn Đệ, Đoàn ., & Mỹ Hạnh, B. . (2022). CHARACTERISTICS OF HOMOCYSTEINE LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH FOOT ULCERS. Vietnam Medical Journal, 512(1). https://doi.org/10.51298/vmj.v512i1.2212

CHARACTERISTICS OF HOMOCYSTEINE LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH FOOT ULCERS

Bùi Thế Long1,, Đoàn Văn Đệ2, Bùi Mỹ Hạnh3
1 National Hospital of Endocrinology
2 Vietnam Military Medical University
3 Hanoi Medical University

Main Article Content

Abstract

Objectives: Study on level of homocysteine (Hcy) in patients with type 2 diabetes with foot ulcers. Subjects and study methods: 401 subjects were inpatients being treated at the National Hospital of Endocrinology since November 2014 (47 patients in the control group, 176 patients with type 2 diabetes with foot ulcers and 178 patients with type 2 diabetes without foot ulcers.). Research Methods: A cross-sectional descriptive study. Results: The average concentration of Homocytein in the control group was 7.49± 1.25; diabetes group without foot ulcers 9.38 ± 4.96 and diabetes with foot ulcers 12.69 ± 4.91 (p < 0.001). Homocysteine concentrations were higher in man than in woman (diabetes with foot ulcers: woman 13.66 ± 4.86 vs man 11.27 ± 4.66; diabetes without foot ulcer: woman 10.43 ± 5.34 vs man 8.70 ± 2.76; p<0.05). Homocysteine concentrations in hypertensive patients were higher than those without hypertension (diabetes with foot ulcers: hypertension 13.28 ± 5.04 vs non-hypertension 11.16 ± 4.23; diabetes without foot ulcers: hypertension 10.59 ± 5.29 vs non-hypertension 8.39 ± 2.23; p < 0.05). Conclusion: Homocysteine levels in the diabetic foot ulcer group were higher than in the diabetic foot without ulcer group and the control group. Homocysteine levels are higher in men than in women; hypertensive patients higher than non-hypertensive patients.

Article Details

Keywords

homocysteine, diabetes mellitus, diabetic foot ulcer

References

1. Holman N., Young B., Gadsby R. (2015), "Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK", Diabet Med. 32(9), 1119-20.
2. Sonkar S K, Sonkar G K, Soni D, et al, (2013), "Plasma Homocysteine level and its clinical correlation with type 2 diabetes mellitus and its complications", International Journal of Diabetes in Developing Countries. 34(1), pp.3-6.
3. Nguyễn Thị Thanh Thủy (2018), Nghiên cứu nồng độ Homocystien huyết tương ở bệnh nhân đái tháo đường typ 2 có hội chứng động mạch vành cấp, Luận án tiến sĩ y học, Học viện Quân y, Hà Nội.
4. Nguyễn Thị Ngọc Huyền (2020), Nghiên cứu độ dày lớp nội trung mạc động mạch cảnh và các yếu tố liên quan ở bệnh nhân đái tháo đường typ 2 có biến chứng bệnh lý thận mạn, Luận án tiến sĩ y học, Trường đại học Y Hà Nội, Hà Nội.
5. Ala O. A., Akintunde A. A., Ikem R. T. et al (2017), "Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria", Diabetes Metab Syndr. 11 Suppl 2, S803-s809.
6. Cohen E., Margalit I., Shochat T. et al (2019), "Gender differences in homocysteine concentrations, a population-based cross-sectional study", Nutr Metab Cardiovasc Dis. 29(1), 9-14.
7. Esse R., Barroso M., Castro R et al (2019), "The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art". 20(4).