ĐÁNH GIÁ HIỆU QUẢ TRÊN SIÊU ÂM VÀ CỘNG HƯỞNG TỪ CỦA LIỆU PHÁP ĐIỀU TRỊ THOÁI HÓA KHỚP GỐI BẰNG HUYẾT TƯƠNG GIÀU TIỂU CẦU KẾ HỢP VỚI TẾ BÀO GÔC TRUNG MÔ TỪ MÔ MỠ TỰ THÂN

Abstract

Aim: To evaluate the results based on ultrasound and magnetic resonance of knee osteoarthritis therapy with platelet-rich plasma in combination with mesenchymal stem cell  from autologous adipose tissue. Objects and methods. 30 patients, 26 female, 4 male, mean age 58.63 ± 11.11, mean disease duration 5.3 ± 4.6 years, respectively 60 knee joints were diagnosed with osteoarthritis at stage II - III according to the Kellgren and Lawrence classifications. After ultrasound and magnetic resonance imaging, all patients were injected with platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue into both knee joints. Results: After 12 months of treatment with platelet-rich plasma injection combined with mesenchymal stem cells from autologous adipose tissue: The thickness of articular cartilage on ultrasound increased significantly from 2.08±0.36mm to 2 ,48±0.36 mm with p<0.05.  There were 52 joints with increased cartilage thickness, equivalent to 86.67%. The surface of articular cartilage on magnetic resonance in all positions of the knee joint has improved, the difference is statistically significant. Particularly, the patellar joint improved from 1.56 ± 0.25 mm to 1.64 ± 0.21 mm with p < 0.05. ConclussionThe treatment of knee osteoarthritis with platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue is effective in improving cartilage thickness on ultrasound and magnetic resonance, thereby improving the motor function of the knee joint.