Article Sidebar

PDF
Date Published: 26/04/2022
Abstract Views: 553
Views PDF: 262
DOI: https://doi.org/10.51298/vmj.v512i2.2301
Issue
Vol. 512 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Kim Phượng, T. ., Phong Thu, L. ., & Hồng Trường, N. . (2022). NEOADJUVANT CHEMOTHERAPY FOR INOPERABLE STAGE III BREAST CANCER PATIENTS TREATED AT ONCOLOGY CENTER OF THAI NGUYEN NATIONAL HOSPITAL. Vietnam Medical Journal, 512(2). https://doi.org/10.51298/vmj.v512i2.2301

NEOADJUVANT CHEMOTHERAPY FOR INOPERABLE STAGE III BREAST CANCER PATIENTS TREATED AT ONCOLOGY CENTER OF THAI NGUYEN NATIONAL HOSPITAL

Trần Thị Kim Phượng1,, Lê Phong Thu1, Nguyễn Hồng Trường1
1 Thai Nguyen University of Medicine and Pharmacy

Main Article Content

Abstract

Purpose: To assess the outcome of neoadjuvant chemotherapy on inoperable stage III breast cancer patients. Study method: cross-sectional study design was conducted on 34 inoperable stage III breast cancer patients treated with neoadjuvant chemotherapy at Oncology Center of Thai Nguyen National Hospital from01/01/2017 to 31/12/2020. Retrospective study was carried out to access the clinical and pathological characteristics of patients as well as the treatment response rate, the rate of changing into operable disease and toxicities. Results: the overall clinical response rate was 67,7%, complete response rate: 11,8%; partial response rate: 55,9%; overall pathological response rate: 16,6%; partial pathological response rate: 79,2%; rate of changing into operable disease was 70,6%, of which 95,8% patients received radical surgery. The toxicities were almost at low grades (1,2). Conclusion: neoadjuvant chemotherapy has the effect on downstaging and changing into inoperable stage on inoperable stage III breast cancer patients. The chemotherapy regiments were tolerable with the low grade of toxicities.

Article Details

Keywords

inoperable stage III breast cancer, locally advanced breast cancer, neoadjuvant chemotherapy, response rate

References

1. Lê Thanh Đức (2014), “Nghiên cứu hiệu quả hóa chất bổ trợ trước phẫu thuật phác đồ AP trong ung thư vú giai đoạn III không mổ được. Luận án tiến sĩ Y học. Kết quả bước đầu hóa trị liệu tân bổ trợ phác đồ AP trong ung thư vú giai đoạn III không mổ được”, Luận án tiến sĩ Y học, Trường Đại học Y Hà nội.
2. Lê Phong Thu, Tạ Văn Tờ (2017), “Đặc điểm mô bệnh học ung thư biểu mô tuyến vú giai đoạn II-III sau điều trị hóa chất tiền phẫu tại Bệnh viện K Hà Nội”, Tạp chí nghiên cứu Y học, tập 106, số 1, tr. 56-63.
3. Nguyễn Thị Thủy (2016), “Đánh gia kết quả hóa trị bổ trợ trước phác đồ 4AC-4T trên bệnh nhân ung thư vú giai đoạn III”, Luận văn bác sĩ nội trú, Trường Đại học Y Hà Nội.
4. De Lena M, Varini M, Zucali R, et al (1981). Multimodal treatment for locally advanced breast cancer. Results of chemotherapy- radiotherapy versus chemotherapy-surgery. Cancer Clin Trials (4), 229-236.
5. Perloff M, Lesnick GJ,Korzun A, et al (1988).Combination Chemotherapy With Mastectomy or Radiotherapy for Stage III Breast Carcinoma: A Cancer and Leukemia Group B Study. J Clin Oncol (6), 261-269.
6. Petrelli F, Coinu A, Lonati V, et al. (2016), "Neoadjuvant dose-densechemotherapy for locally advanced breast cancer: a meta-analysis of published studies", Anticancer Drugs, 27 (7), pp. 702-8.
7. Wang, M., Hou, L., Chen, M. (2017), Neoadjuvant Chemotherapy Creates Surgery Opportunities For Inoperable Locally Advanced Breast Cancer. Scientific Reports (7), pp.44673-7.
8. Shet, T., Agrawal, A., Chinoy, R. (2007), “Changes in the tumor grade and biological markers in locally advanced breast cancer after chemotherapy--implications for a pathologist”, Breast J, 13(5), pp.457-64.