ĐẶC ĐIỂM KHÁNG KHÁNG SINH CỦA MỘT SỐ VI KHUẨN GRAM ÂM SINH ENZYME BETA LACTAMASE PHỔ RỘNG PHÂN LẬP TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN NĂM 2018-2020

Abstract

The study used a retrospective study method to evaluate antibiotic resistance of some extended spectrum beta-lactamase-producing gram-negative bacteria (ESBL) isolated at Thai Nguyen central hospital. 2018-2020. Research results: There were 388/1156 (33.5%) ESBL-producing Gram-negative bacteria strains isolated. Among 388 ESBL-producing strains, E.coli had the highest ESBL-producing rate 307 (79.1%), K.pneumoniae 58 (14.9%), Proteus sp 19 (4.9%). The ESBL(+) group of bacteria has a higher rate of antibiotic resistance than the ESBL(-) group, some Cephalosporins have a very high resistance rate such as E.coli: Cefuroxime (90.9%), Ceftazidime (81.2%), Ceftriaxone (92.9%), Cefotaxime (95.7%) and Cefepime (76.4%), K.peumoniae: Cefuroxime (75.7%), Cefotaxime (90.2%) Ceftriaxone (81,6%), Ceftazidime (75%), Cefepime (62.1%), Proteus sp: Cefuroxime (100%), Cefotaxime (100%) Ceftriaxone (80%), Ceftazidime (75%). In addition, some antibiotics belonging to other antibiotic groups also have high resistance rates > 80% - 100% depending on the species of bacteria such as: Ampicillin, Tetracycline, Piperacillln, Trimethoprime – Sulfamethohazole.