Article Sidebar
Views PDF: 201
METABOLIC SYNDROME IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-α HYDROXYLASE DEFICIENCY
Main Article Content
Abstract
A metabolic syndrome (MetS) is a group of risk factors for cardiovascular risks and increased mortality in adults and children. Evidence shows that patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency (CAH) have many factors leading to metabolic syndrome and an increased risk of cardiovascular risks. Objectives: to determine the incidence and characterize the metabolic syndrome in the population of congenital adrenal hyperplasia with 21- α hydroxylase deficiency. Subjects: 52 patients with CAH aged 10 years and older were diagnosed, managed and followed up at Viet Nam National Children’s Hospital. From July 2019 to August 2020. Methods: A cross-sectional description. Results: The incidence of metabolic syndrome in patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency was 15.4% (8/52), all patients with increased waist circumference and hypertriglyceridemia, 7/8 (87.5%) patients with insulin resistance and overweight, obesity, half of the patients have impaired blood glucose, only two patients with hypertension. 5/8 (62.5%) of patients with metabolic syndrome have poor control. Conclusions: Metabolic syndrome is a new problem in patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency.
Article Details
Keywords
metabolic syndrome, congenital adrenal hyperplasia
References
2. Moreira R.P.P., Villares S.M., Madureira G., et al (2013). Obesity and familial predisposition are significant determining factors of an adverse metabolic profile in young patients with congenital adrenal hyperplasia. Horm Res Paediatr, 80(2), 111–118.
3. Ariyawatkul K., Tepmongkol S., Aroonparkmongkol S., et al (2017). Cardio-metabolic risk factors in youth with classical 21-hydroxylase deficiency. Eur J Pediatr, 176(4), 537–545.
4. Improda N., Barbieri F., Ciccarelli G.P., et al (2019). Cardiovascular Health in Children and Adolescents With Congenital Adrenal Hyperplasia Due to 21-Hydroxilase Deficiency. Front Endocrinol (Lausanne), 10, 212.
5. Weiss R., Bremer A.A., and Lustig R.H (2013). What is metabolic syndrome, and why are children getting it?. Ann N Y Acad Sci, 1281(1), 123–40.
6. Charmandari E., Chrousos G.P (2006). Metabolic syndrome manifestations in classic congenital adrenal hyperplasia: Do they predispose to atherosclerotic cardiovascular disease and secondary polycystic ovary syndrome?. Ann N Y Acad Sci, 1083, 37–53.
7. Paizoni L., Auer M.K., Schmidt H., et al (2020). Effect of androgen excess and glucocorticoid exposure on metabolic risk profiles in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Steroid Biochem Mol Biol, 197, 105540.