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METABOLIC SYNDROME IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-α HYDROXYLASE DEFICIENCY
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Abstract
A metabolic syndrome (MetS) is a group of risk factors for cardiovascular risks and increased mortality in adults and children. Evidence shows that patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency (CAH) have many factors leading to metabolic syndrome and an increased risk of cardiovascular risks. Objectives: to determine the incidence and characterize the metabolic syndrome in the population of congenital adrenal hyperplasia with 21- α hydroxylase deficiency. Subjects: 52 patients with CAH aged 10 years and older were diagnosed, managed and followed up at Viet Nam National Children’s Hospital. From July 2019 to August 2020. Methods: A cross-sectional description. Results: The incidence of metabolic syndrome in patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency was 15.4% (8/52), all patients with increased waist circumference and hypertriglyceridemia, 7/8 (87.5%) patients with insulin resistance and overweight, obesity, half of the patients have impaired blood glucose, only two patients with hypertension. 5/8 (62.5%) of patients with metabolic syndrome have poor control. Conclusions: Metabolic syndrome is a new problem in patients with congenital adrenal hyperplasia due to 21-α hydroxylase deficiency.
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Keywords
metabolic syndrome, congenital adrenal hyperplasia
References
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