Article Sidebar

PDF
Date Published: 17/06/2022
Abstract Views: 744
Views PDF: 280
DOI: https://doi.org/10.51298/vmj.v513i2.2431
Issue
Vol. 513 No. 2 (2022)
Section
Các bài báo
How to Cite
Thùy Hương, Đỗ ., Thị Ngọc Yến, T. ., Ngọc Dung, L. ., Thị Minh Khai, N. ., Phúc Hoàn, N. ., Thanh Hoa, N. ., Tiến Tùng, D. ., Thị Mai Lương, Đặng ., & Mạnh Hà, N. . (2022). THE USE OF AUTOLOGOUS PLATELET-RICH PLASMA IN WOMEN UNDERGOING IN VITRO FERTILIZATION WITH A THIN ENDOMETRIUM OR REPEATED IMPLANTATION FAILURE. Vietnam Medical Journal, 513(2). https://doi.org/10.51298/vmj.v513i2.2431

THE USE OF AUTOLOGOUS PLATELET-RICH PLASMA IN WOMEN UNDERGOING IN VITRO FERTILIZATION WITH A THIN ENDOMETRIUM OR REPEATED IMPLANTATION FAILURE

Đỗ Thùy Hương1,, Trịnh Thị Ngọc Yến1, Lê Ngọc Dung1, Nguyễn Thị Minh Khai1, Nguyễn Phúc Hoàn1, Nguyễn Thanh Hoa1, Dương Tiến Tùng1, Đặng Thị Mai Lương1, Nguyễn Mạnh Hà1
1 Hanoi Medical University

Main Article Content

Abstract

A clinical trial study to evaluate the effectiveness of autologous platelet-rich therapy intrauterine infusion in patients with thin endometrium (TE) and patients with repeated implantation failure (RIF) in IVF. Results: in TE group, the thickness of the endometrium after PRP infusion increased significantly compared to before (5,8 ± 1.01 mm vs. 6,73 ± 0,72 mm, p=0,002). The pregnancy rate (PR), clinical pregnantcy rate (CPR) and ongoing pregnancy rate (OPR) in TE group were 54,5%; 54,5% and 45,5%, respectively. In RIF group, the PR, CPR, OPR were 23,08%; 23,08% and 7,7%; respectively. Conclusions: Intrauterine autologous PRP infusion improved significantly the endometrial thickness and successful rate in IVF in some patients with thin endometrium. No improvement in pregnancy rate was observed in RIF group used PRP therapy.

Article Details

Keywords

Platelet-Rich Plasma (PRP), thin endometrium, Repeated Implantation Failure (RIF), In Vitro Fertilization (IVF)

References

1. Alam V, Bernardini L, Gonzales J, Asch RH, Balmaceda JP. A prospective study of echographic endometrial characteristics and pregnancy rates during hormonal replacement cycles. J Assist Reprod Genet. 1993;10(3):215-219. doi:10.1007/BF01239224
2. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007;87(1):53-59. doi:10.1016/j.fertnstert.2006.05.064
3. El-Toukhy T, Coomarasamy A, Khairy M, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril. 2008;89(4):832-839. doi:10.1016/j.fertnstert.2007.04.031
4. Al-Ghamdi A, Coskun S, Al-Hassan S, Al-Rejjal R, Awartani K. The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocrinol. 2008;6:37. doi: 10.1186/1477-7827-6-37
5. Wu Y, Gao X, Lu X, et al. Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration. Reprod Biol Endocrinol. 2014;12:96. doi:10.1186/1477-7827-12-96
6. Bu Z, Sun Y. The Impact of Endometrial Thickness on the Day of Human Chorionic Gonadotrophin (hCG) Administration on Ongoing Pregnancy Rate in Patients with Different Ovarian Response. PLoS One. 2015;10(12):e0145703. doi:10.1371/journal.pone.0145703
7. Shufaro Y, Simon A, Laufer N, Fatum M. Thin unresponsive endometrium--a possible complication of surgical curettage compromising ART outcome. J Assist Reprod Genet. 2008;25 (8):421-425. doi:10.1007/s10815-008-9245-y
8. Kasius A, Smit JG, Torrance HL, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(4):530-541. doi:10.1093/ humupd/dmu011
9. Chang Y, Li J, Chen Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015;8(1):1286-1290.
10. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Azargashb E. Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT. Int J Reprod Biomed. 2019;17(6):443-448. doi:10.18502/ ijrm.v17i6.4816