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Date Published: 17/06/2022
Abstract Views: 210
Views PDF: 149
DOI: https://doi.org/10.51298/vmj.v513i2.2438
Issue
Vol. 513 No. 2 (2022)
Section
Các bài báo
How to Cite
Công Duy, T. ., & Quang Bình, T. . (2022). A SURVEY OF ACE I/D GENETIC VARIANT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Vietnam Medical Journal, 513(2). https://doi.org/10.51298/vmj.v513i2.2438

A SURVEY OF ACE I/D GENETIC VARIANT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Trần Công Duy1,, Trương Quang Bình1
1 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Objects: to assess the genetype and allele proportion of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with acute myocardial infarction (AMI). Subjects and methods: This was a cross-sectional and descriptive study among AMI patients at Department of Cardiology and Department of Invasive Cardiology, Cho Ray Hospital between January 2020 and July 2020. All patients were determined ACE I/D genotypes by polymerase chain reactions. Results: A total of 130 AMI patients (mean age 65.7±11.9; 67.7% men) were enrolled in the study. Dyslipidemia (90.3%) and hypertension (87.7%) were the most frequent cardiovascular risk factors. The rate of patients with ST-segment elevation MI was 51.5% and Killip I class accounted for 76.2%. The rate of II, ID, and DD genotypes of ACE I/D polymorphism were 42.3%, 41.5%, and 16.2%, respectively. The I and D allele proportion of this genetic variant were 59.2% and 40.8%. Conclusions: DD genotype and D allele of ACE I/D genetic variant have the lowest proportion in patients with AMI.

Article Details

Keywords

genotype, allele, ACE I/D, acute myocardial infarction

References

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