SO SÁNH KẾT QUẢ GIẢI GIÃN CƠ CỦA SUGAMMADEX LIỀU 1 MG/KG HOẶC 0,5 MG/KG VỚI NEOSTIGMIN LIỀU 40 MCG/KG TẠI MỨC TOF 0,25

Abstract

Residual muscle relaxants after surgery are a common in anaesthesia and raise the airway urgency that need to use of muscle relaxants monitor as well as decurarisation drugs. Sugamadex is one kind of decurarization drug with many advantages, but the price is still high. The use of smaller dose has not been studied in Vietnam as well as in the world. We conducted a study to compare the decurarizative results of sugammadex 1mg/kg or 0.5kg/kg with neostigmine 40 mcg/kg at a TOF of 0.25. Prospective, clinical intervention study wasconducted from March 2021 to October 2021 on 90 patients, randomly divided into 3 groups: group I - sugammadex 1mg/kg, group II - sugammadex 0.5mg/kg, group III - neostigmine 40mcg/kg with atropine sulphate 15 mcg/kg. The results showed that the recovery time for TOF ≥ 0.9 gradual faster in the following order: sugammadex 1mg/kg, sugammadex 0.5mg/kg and neostigmin 40 µg/kg, and the sugammadex group did not change the rhythm, heart rate and blood pressure before and after relaxation. Meanwhile, other undesirable effects such as bradycardic, dry mouth, increased sputum secretion, etc increased in the group neotigmin. Conclusion: it is possible to use a lower dose than the theory when the patient has recovered partial muscle relaxation. That doses were still effectived and also limited some side effects when compared to neostigmine.