Article Sidebar

PDF
Date Published: 17/06/2022
Abstract Views: 266
Views PDF: 143
DOI: https://doi.org/10.51298/vmj.v513i2.2461
Issue
Vol. 513 No. 2 (2022)
Section
Các bài báo
How to Cite
Công Duy, T. ., & Quang Bình, T. . (2022). GENOTYPE AND ALLELE PROPORTION OF AGT M235T POLYMORPHISM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. Vietnam Medical Journal, 513(2). https://doi.org/10.51298/vmj.v513i2.2461

GENOTYPE AND ALLELE PROPORTION OF AGT M235T POLYMORPHISM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Trần Công Duy1,, Trương Quang Bình1
1 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Objects: to survey the genotype and allele proportion of AGT M235T gene polymorphism in patients with acute myocardial (AMI). Subjects and methods: This was a cross-sectional and descriptive study in patients with AMI at the Department of Cardiology and Department of Invasive Cardiology, Cho Ray Hospital from January 2020 to June 2020. AGT M235T gene polymorphism was determined by polymerase chain reaction (PCR) at the Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City. Results: During the study period, 120 patients with AMI had a mean age of 64.5±11.5 years and 69.2% were men. Hypertension (86.7%) and dyslipidemia (86.2%) were the most common risk factors for coronary artery disease. The proportion of ST-segment elevation myocardial infarction was 55.0% and the Killip I class was the most frequent (78.3%). The rate of MM, MT, and TT genotypes of AGT M235T  polymorphism were 0%, 21.7%, and 78.3% respectively. The proportion of M and T alleles were 17.8% and 82.2%. Conclusions: TT genotype and T allele of AGT M235T genetic variant have the highest proportion in patients with AMI.

Article Details

Keywords

genotype, allele, AGT M235T, acute myocardial infarction

References

1. Araujo MA, Goulart lR, Cordeiro eR, et al (2005), “Genotypic interactions of renin-angiotensin system genes in myocardial infarction”, Int J Cardiol, 103, pp. 2732.
2. Kamitani A, Rakugi H, Higaki J, et al (1995), “Enhanced predictability of myocardial infarction in Japanese by combined genotype analysis”, Hypertension, 25, pp. 950-953.
3. Lê Phước Trung, Đỗ Hữu Nghị, Trần Đức Hùng (2021), “Nghiên cứu nồng độ NT-proBNP huyết thanh và mối liên quan với mức độ tổn thương động mạch vành bằng thang điểm SYNTAX II ở bệnh nhân nhồi máu cơ tim cấp”, Tạp chí Y Học Việt Nam, 509 (2), tr. 334-338.
4. Mehri S, Mahjoub S, Farhati A, et al (2011), “Angiotensinogen gene polymorphism in acute myocardial infarction patients”, J Renin Angiotensin Aldosterone Syst, 12, pp. 42-47.
5. Ngô Tuấn Hiệp (2017), So sánh giá trị của các thang điểm nguy cơ trong tiên lượng bệnh nhân nhồi máu cơ tim cấp, Luận án Tiến sĩ Y học, Đại học Y Dược TP. Hồ Chí Minh.
6. Nguyễn Văn Tuấn, Phạm Hồng Phương (2021), “Một số đặc điểm lâm sàng, cận lâm sàng và kết quả chụp động mạch vành qua da ở bệnh nhân nhồi máu cơ tim cấp”, Tạp chí Y Học Việt Nam, 502 (1), tr. 180-184.
7. Olivieri O, Stranieri C, Girelli D, et al (2001), “Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease”, J Hypertens, 19, pp. 879–884.
8. Thygesen K, Alpert JS, Jaffe AS, et al(2018), “Fourth universal definition of myocardial infarction”, Circulation, 138, e618–e651.