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Date Published: 17/06/2022
Abstract Views: 321
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DOI: https://doi.org/10.51298/vmj.v513i2.2495
Issue
Vol. 513 No. 2 (2022)
Section
Các bài báo
How to Cite
Trường Giang, Đào ., Việt Tú, T. ., Văn Thái, N. ., & Tiến Thịnh, N. . (2022). INITIAL RESULT ASSESSMENT OF THE USE OF AUTOLOGOUS BONE MARROW STEM CELLS IN 5 PATIENTS WITH ALCOHOL-INDUCED DECOMPENSATED CIRRHOSIS. Vietnam Medical Journal, 513(2). https://doi.org/10.51298/vmj.v513i2.2495

INITIAL RESULT ASSESSMENT OF THE USE OF AUTOLOGOUS BONE MARROW STEM CELLS IN 5 PATIENTS WITH ALCOHOL-INDUCED DECOMPENSATED CIRRHOSIS

Đào Trường Giang1,, Trần Việt Tú1, Nguyễn Văn Thái2, Nguyễn Tiến Thịnh2
1 ietnam Military Medical University, Ministry of Defence
2 108 Military Central Hospital, Ministry of Defence

Main Article Content

Abstract

Objectives: To study the feasibility and initial results of autologous bone marrow stem cell therapy in patients with alcoholic decompensated cirrhosis. Subjects and methods: 5 patients with alcoholic decompensated cirrhosis (age 47-60), eligible to participate in the study, were recruited from February 2021 to June 2021. Using hematopoietic stem cells, extracted from 200-300ml of bone marrow fluid, and injected into the liver through the hepatic artery. Patients were followed up for 6 months after transplantation. Results: no complications related to the use of stem cells were recorded in the patients, the stem cell mass was satisfactory, the CD34+ cell concentration/µl of bone marrow fluid collected was 51.55 27.42; The mean absolute number of CD34+ cells was 15.46 8.22x106. Albumin concentration after treatment increased after treatment compared to the time of T0, but the difference was not statistically significant with p > 0.05; There was no improvement with bilirubin and prothrombin. Conclusion: Stem cell transplantation in subjects with alcoholic cirrhosis is feasible, no complications related to the use of stem cells have been recorded, the initial results are not statistically significant.

Article Details

Keywords

cirrhosis, stem cell transplantation, bone marrow, alcoholic liver disease

References

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