EVALUATE ACUTE TOXICITY AND SEMI-PERMANENT TOXICITY OF THAO MOC – SV

Trần Trọng Dương1,, Lê Văn Quân2
1 19-8 Hospital, Ministry of Public Security
2 Vietnam Military Medical University, Ministry of Defence

Main Article Content

Abstract

Conducted acute toxicity and semi-permanent toxicity studies of THAO MOC - SV conducted on rats in the laboratory, showed that: With oral dose of THAO MOC - SV from 346mg/kg to 2076mg/kg, no signs were observed. acute toxicity or death in white mice. The LD50 dose of THAO MOC – SV if any is greater than 2076mg/kg; White rat taking THAO MOC - SV for 28 days with 2 doses of 214.52mg/kg and 643.56mg/kg did not have any effect on hematopoietic function, liver function and kidney function with the morphology of liver and kidney function. reward average. So the above results, we conclude: THAO MOC - SV is safe, does not cause acute and semi-permanent toxicity in experimental animals.

Article Details

References

1. Bộ Y tế (2015), Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu, Hà Nội, ngày 27 tháng 10 năm 2015.
2. Đỗ Trung Đàm (2014), Phương pháp xác định độc tính của thuốc, Nhà xuất bản Y học, Hà Nội.
3. Ariana Aline Silva, Mauro Sérgio Perilhão, Marina Caldeira, Danilo Bocalini & Romeu Rodrigues de Souza (2018), “Reference database of hematological parameters for growing and aging rats”, The Aging Male, 21:2, 145-148.
4. D Kanjanapothi, A Panthong, N Lertprasertsuke et al (2004), “Toxicity of crude rhizome extract of Kaempferia galanga L. (Proh Hom)”, J Ethnopharmacol, 2004; 90(2-3): 359-65.
5. https://www.drugfuture.com/toxic/q51-q720.html
6. https://www.drugfuture.com/toxic/q73-q836.html
7. Kim HY, Zuo G, Lee SK, Lim SS (2020), “Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice”, Food Sci Nutr, 2020; 8(5): 2242-2250.
8. Nafiu Bidemi Abdulrazaq, Maung Maung Cho, Ni Ni Win, Rahela Zaman, Mohammad Tariqur Rahman (2012), “Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats”, Br J Nutr, 2012; 108(7): 1194-201.
9. Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human (2016), J Basic Clin Pharm, 2016;7(2):27-31.