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TO EVALUATE THE SAFTY AND CARTILAGE GROWTH LEVELS OF KNEE OSTEOARTHRITIS THERAPY BY PLATELET RICH PLASMA IN COMBINATION WITH MESENCHYMAL STEM CELLS FROM AUTOLOGOUS ADIPOSE TISSUE
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Abstract
Aim: The aim of this study is to evaluate the safety and cartilage growth levels on magnetic resonance of knee osteoarthritis therapy by platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue. Objects and methods: 60 knee joints in 30 patients, 26 female, 4 male, mean age 58.63 ± 11.11 years, were diagnosed with degenerative disease according to American Society of Rheumatology (ACR) stage II - III according to Kellgren and Lawrence. All were injected with autologous platelet-rich plasma mixture extracted by PRP kit, APC 30 PRP PRCEDURE PRAK and autologous abdominal adipose stem cells were extracted by ADI-25-01 ADIPOSEPRCEDURE PRAK kit with machine Harvest stem cells from TERUMO BCT- USA. Result: The rate of knee pain after 3 hours of injection is 15/60 joints (25%). In which 6 cases of pain persisted for more than 24 hours, 10% of the knee joints effusion after injection. No patient showed infection of joints or soft tissues around the joints after injection. There were 73.3% patients with no persistent pain after fat removal and no bleeding under the skin of the abdomen after fat removal. After 12 months of treatment: 52/60 (86.77%) joints had a change in cartilage thickness and the cartilage thickness of the patellar joints increased from 1.56 ± 0.09 mm before treatment up to 1.65 ± 0.09 mm after treatment. Conclusion: The treatment of knee osteoarthritis with platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue is safe, has a low rate of local complications, and has no infectious complications as well. whole body accident. Improve articular cartilage thickness articular cartilage thickness on magnetic resonance thereby improving the mobility function of the knee joint.
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References
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