Article Sidebar
Views PDF: 220
TO EVALUATE THE SAFTY AND CARTILAGE GROWTH LEVELS OF KNEE OSTEOARTHRITIS THERAPY BY PLATELET RICH PLASMA IN COMBINATION WITH MESENCHYMAL STEM CELLS FROM AUTOLOGOUS ADIPOSE TISSUE
Main Article Content
Abstract
Aim: The aim of this study is to evaluate the safety and cartilage growth levels on magnetic resonance of knee osteoarthritis therapy by platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue. Objects and methods: 60 knee joints in 30 patients, 26 female, 4 male, mean age 58.63 ± 11.11 years, were diagnosed with degenerative disease according to American Society of Rheumatology (ACR) stage II - III according to Kellgren and Lawrence. All were injected with autologous platelet-rich plasma mixture extracted by PRP kit, APC 30 PRP PRCEDURE PRAK and autologous abdominal adipose stem cells were extracted by ADI-25-01 ADIPOSEPRCEDURE PRAK kit with machine Harvest stem cells from TERUMO BCT- USA. Result: The rate of knee pain after 3 hours of injection is 15/60 joints (25%). In which 6 cases of pain persisted for more than 24 hours, 10% of the knee joints effusion after injection. No patient showed infection of joints or soft tissues around the joints after injection. There were 73.3% patients with no persistent pain after fat removal and no bleeding under the skin of the abdomen after fat removal. After 12 months of treatment: 52/60 (86.77%) joints had a change in cartilage thickness and the cartilage thickness of the patellar joints increased from 1.56 ± 0.09 mm before treatment up to 1.65 ± 0.09 mm after treatment. Conclusion: The treatment of knee osteoarthritis with platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue is safe, has a low rate of local complications, and has no infectious complications as well. whole body accident. Improve articular cartilage thickness articular cartilage thickness on magnetic resonance thereby improving the mobility function of the knee joint.
Article Details
References
2. Bùi Hải Bình (2016). Nghiên cứu điều trị bệnh thoái hóa khớp gối nguyên phát bằng liệu pháp huyết tương giàu tiểu cầu tự thân. Luận án tiến sỹ Y học, Trường đại học Y Hà Nội.
3. Fransen M, L. Bridgett, L. March et al (2011). The epidemiology of osteoarthritis in Asia. Int J Rheum Dis, 14 (2), 113-121.
4. Khanh Hong-Thien Bui, Triet Dinh Duong, Nhan Thanh Nguyen et al (2014). Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study. Biomedical Research and Therapy, 1, 02-08.
5. Thu Phạm Hoài Thu (2017) “ Nghiên cứu kết quả điều trị bệnh thoái hóa khớp gối nguyên phát bằng liệu pháp tế bào gốc mô mỡ tự thân”. Luận án tiến sỹ Y học, Trường Đại học Y Hà Nội.
6. Tiến Trần Viết và cộng sự (2015). Nghiên cứu ứng dụng tế bào gốc tự thân trong điều trị bệnh thoái hóa khớp. Đề tài độc lập cấp nhà nước, Học viện quân Y.
7. Yong-Gon Koh, Seung-Bae Jo, Oh-Ryong Kwon et al (2012). Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis. The Journal of Arthroscopic and Related Surgery, 29 (4), 748-755.
8. Liang-jing Lu et al (2016). Treatment with human adipose- derived mesenchymal stem cells for knee osteoarthritis. NCT 021626693. The 18th Congress of Asia Pacific League of Association for Rheuatology (APLAR 2016). Shanghai, China.
9. Centeno CJ, Schultz J, Cheever M. et al(2010). Safety and complications reporting on the re- implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem cell Res Ther, 5 (1), 81-93.