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Date Published: 20/06/2022
Abstract Views: 499
Views PDF: 310
DOI: https://doi.org/10.51298/vmj.v514i1.2552
Issue
Vol. 514 No. 1 (2022)
Section
Các bài báo
How to Cite
Văn Hùng, P. ., Đức Anh, M. ., Anh Quân, Đặng ., Thanh Tùng, N. ., Thị Ánh Nhật, H. ., Trung Hiếu, B. ., Bảo Nam, Đỗ ., Thị Hồng Hạnh, Đỗ ., & Thị Thanh Duyên, N. . (2022). FORMULATION AND PREPARATION OF METRONIDAZOLE COLON-TARGETED MICROCAPSULES. Vietnam Medical Journal, 514(1). https://doi.org/10.51298/vmj.v514i1.2552

FORMULATION AND PREPARATION OF METRONIDAZOLE COLON-TARGETED MICROCAPSULES

Phạm Văn Hùng1, Mai Đức Anh2, Đặng Anh Quân1, Nguyễn Thanh Tùng1, Hoàng Thị Ánh Nhật1, Bùi Trung Hiếu1, Đỗ Bảo Nam1, Đỗ Thị Hồng Hạnh1, Nguyễn Thị Thanh Duyên1,
1 Hanoi University of Pharmacy
2 Hai Phong Pharmaceutical Joint Stock Company

Main Article Content

Abstract

Objectives: To develop a formulation for metronidazole (MTZ) microcapsules and investigate the influence of the multilayered coating system intending to release the drug in the colon. Methods: MTZ microcapsules were prepared by coagulation method and then coated by the film coating method. Results: The final microcapsules limited MTZ released during the first five hours at pH 1.2 and 7.4 (simulating the upper gastrointestinal tract) and yielded a high rate of MTZ release at pH 6.8 (simulating the colon environment).

Article Details

Keywords

metronidazole (MTZ), microcapsules, coagulation method, multilayered coating, colon-targeted

References

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