ĐẶC ĐIỂM VIÊM TEO NIÊM MẠC DẠ DÀY THEO PHÂN LOẠI OLGA VÀ MỘT SỐ YẾU TỐ LIÊN QUAN CỦA BỆNH NHÂN ĐẾN KHÁM TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Background: The diagnosis of gastric cancer by OLGA is very accurate but can be assessed by simpler methods. Objective: Determine pathological characteristics and factors related to atrophic gastritis.
Materials and methods: Design a cross-sectional description, recording the pathological and laboratory characteristics of 121 patients who came for examination at Ha Medical University Hospital. Results: The mean age of the subjects was 53.2 ± 11.4 years old. The rate of men is lower than that of women, the rate of Hp infection is 66.9%. 61.1% of subjects had atrophic gastritis according to OLGA level I, 31.4% grade II, 5.0% grade III, and 2.5% grade IV. The degree of atrophic gastric mucosal inflammation was related to Hp infection status with p < 0.05. As age increases, OLGA levels increase. The concentration of PGI, II, and the ratio of PGI/II decreased according to the severity of atrophic gastritis according to OLGA with a statistically significant difference with p < 0.05. PGI concentration decreased in severe atrophic gastritis with a strong correlation r = - 0.512 with p < 0.05; The ratio of PGI/II decreased in the presence of severe atrophic gastritis with the mean correlation r = - 0.317 with p < 0.05. With PG threshold (+) when PGI < 70 ng/ml and ratio PGI/II < 3, pepsinogen index is not able to distinguish severe atrophic gastritis (OLGA III-IV stage) from severe atrophic gastritis. mild atrophic gastritis with p = 0.619. Conclusion: There is a relationship between Hp infection with increased severity in the OLGA classification. PGI concentration and PGI/II ratio have an inverse correlation with the degree of atrophic gastritis according to OLGA classification. It has not been found that the threshold of PGI < 70 ng/ml and PGI/II < 3 can distinguish severe and mild atrophic inflammation of the gastric mucosa according to the OLGA classification.