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Date Published: 21/06/2022
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DOI: https://doi.org/10.51298/vmj.v514i2.2626
Issue
Vol. 514 No. 2 (2022)
Section
Các bài báo
How to Cite
Huy Thịnh, T. ., Hoàn, L. ., & Vân Khánh, T. . (2022). IDENTIFICATION OF EGFR MUTATION AND EML4-ALK, ROS1 FUSION GENE IN NON SMALL CELL LUNG CANCER. Vietnam Medical Journal, 514(2). https://doi.org/10.51298/vmj.v514i2.2626

IDENTIFICATION OF EGFR MUTATION AND EML4-ALK, ROS1 FUSION GENE IN NON SMALL CELL LUNG CANCER

Trần Huy Thịnh1,, Lê Hoàn1, Trần Vân Khánh1
1 Hanoi Medical University

Main Article Content

Abstract

Targeted therapy is an effective method for treatment of non small cell lung cancer (NSCLC), especially in patients group carrying EGFR, EML4-ALK, ROS1 mutation. However, not all of patients have good response with targeted drugs. Many previous studies demonstrated the close relationship between EGFR and EML4-ALK, ROS1 rearrangement mutation and the response of targeted drugs with tumor. Objectives: Identifying EGFR mutation and EML4-ALK, ROS1 rearrangement mutations in NSCLC patients by realtime PCR and FISH methods. Methods: 135 NSCLC patients were selected for this study; realtime PCR and FISH methods were used to identify EGFR mutation and EML4-ALK, ROS1 rearrangement mutation. Results: 69/135 (51,1%) of NSCLC patients have mutation in exon 19, 20 and 21 of EGFR gene; 9/135 (6,7%) of NSCLC patients have EML4-ALK rearrangement mutation and 3/135 (2,2%) of NSCLC patients have ROS1 rearrangement mutation.

Article Details

Keywords

Non small cell lung cancer, EGFR mutation, EML4-ALK, ROS1 rearrangement mutation, Targeted therapy

References

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