ĐÁNH GIÁ TÁC DỤNG KHÔNG MONG MUỐN CỦA GÂY TÊ TỦY SỐNG BẰNG BUPIVACAIN KẾT HỢP VỚI CÁC LIỀU MORPHIN KHÁC NHAU TRONG PHẪU THUẬT CHẤN THƯƠNG CHI DƯỚI

Abstract

Objective: To compare the side effects of spinal anesthesia by 8mg bupivacaine 0.5% combined with 100mcg, 200mcg, 300mcg morphine in lower extremity surgery at 105 Military Hospital from November 2018 to April 2019. Method: prospective randomized controlled trial interventional study. The patients were divided into three random groups: Group I included 40 patients who received 8 mg bupivacaine combined with 0,1 mg morphine. Group II consisted of 40 patients who received 8 mg bupivacaine combined with 0,2 mg morphine. Group III consisted of 40 patients who received 8 mg bupivacaine combined with 0,3 mg morphine. Results: Pulse rate and blood pressure changes as well as respiratory changes: SpO2, respiratory rate at the time performing the study was not remarkable in normal range and there was no difference in three groups with p> 0, 05. Other effects such as urinary retention, vomiting, trembling and headache did not differ between 3 groups. Conclusions: Analgesia morphine dose: should apply dose of 0,3mg due to having the same side effects as doses of 0,2mg or 0,1mg but more effective analgesia.