ĐÁNH GIÁ HIỆU QUẢ CAN THIỆP CỦA HOẠT ĐỘNG DƯỢC LÂM SÀNG TRONG VIỆC SỬ DỤNG NHÓM KHÁNG SINH CARBAPENEM TẠI KHOA HỒI SỨC TÍCH CỰC - CHỐNG ĐỘC BỆNH VIỆN ĐA KHOA TỈNH NINH THUẬN

Abstract

Objectives: To investigate the prevalence of antimicrobial resistance, the pattern of carbapenem use and to evaluate the initial intervention of clinical pharmacists on carbapenem use at the Intensive Care and Poison Control Department at Ninh Thuan Provincial General Hospital. Subjects and methods: A cross-sectional study was conducted, comparing two phases with phase 1 (pre-intervention phase) from 07/2020 to 12/2020 and phase 2 (intervention phase) from 01/2021 to 07/2021. Criteria for the critical use of antibiotics were based on Guidelines for using antibiotics of the Ministry of Health, 2015; Antibiotic Usage Guidelines of Ninh Thuan General Hospital, 2017 and The Sanford Guide to Antimicrobial Therapy, 2020. Results: In both phases, Gram-negative bacteria accounted for the majority of bacteria isolates and had a high rate of carbapenem resistance. Imipenems were more prevalent among carbapenems (over 90% of all medical records). With clinical pharmacist interventions, the appropriate use of antibiotics was increased to 70.5%; recommendations from pharmacists for dose optimization were approved in 88.1% of cases and 48.9% of patients recovered from the disease. Conclusion: After the intervention of a clinical pharmacist, the appropriateness of antibiotic use was improved. This shows the role of clinical pharmacists in the antimicrobial stewardship programs for antibiotics in general and carbapenems in particular.